1 / 10

Association between GRIK3 polymorphism and schizophrenia in the Indian population

Association between GRIK3 polymorphism and schizophrenia in the Indian population. By Jelena Cavric. Schizophrenia is. A multifactorial disease Environment Genetics

conan
Download Presentation

Association between GRIK3 polymorphism and schizophrenia in the Indian population

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Association between GRIK3 polymorphism and schizophrenia in the Indian population By Jelena Cavric

  2. Schizophrenia is • A multifactorial disease • Environment • Genetics • No single gene has been found yet, but recent studies have shown the association with single nucleotide polymorphisms with the disease

  3. ETMOLOGY • Despite the etymology of the term from the Greek roots skhizein (σχίζειν, "to split") and phrēn, phren- (φρήν, φρεν-; "mind"), schizophrenia does not imply a "split mind" and it is not the same as dissociative identity disorder (previously known as multiple personality disorder or split personality), a condition with which it is often confused in public perception. • Coined by eugen bueler

  4. Role of Glutamate • Primary excitatory neurotransmitter in hippocampus and cortex. • Risk of excitotoxicity- accum of glutamate receptors • Excitotoxicity in GRIK3 subunit of Glutamate 7 receptor • T/G SNP --> serine -alanine • If guanine was found this was associated with increased risk of Schizophrenia in Caucasians

  5. Question is: is it the same in the Indian population?

  6. Experiment: • Patients: subtypes:paranoid (70%), undifferentiated (25%), catatonic(5%) • Diagnosis: interview, medical records, clinical observations, history, family history • Lab: DNA extraction.PCR. GRIK3 subunit detected and analyzed.

  7. Results: • GRIK 3 ser310ala polymorphism associated with schizophrenia in Indian patients too • GRIK 3 Alanine allele was found to be increased by 44% compared to their healthy controls • This conclusion GRIK3 association in Indian and western European population with Schizophrenia

  8. Conclusion: • Although in Indians and Europeans Ala310allele plays role in Schizophrenia, • No correlation has been found in Japanese and Chinese population. • Thus the disease susceptibility gene is Geographically Restricted • This again proves that Schizophrenia is a multifactorial disease • Only that some people with Ala310GRIK3 allele have a predisposition to getting Schizophrenia

  9. Indian media’s depiction of schizophrenia • 15th park avenue -movie (English movie) • Starring konkona sen sharma , Rahul Bose , Shabana Aazmi , Vahida Rehman

  10. That's all

More Related