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Cryoprecipitate

Cryoprecipitate. Laura Cooling MD, MS Associate Medical Director Transfusion Medicine. Cryoprecipitate. Prepared from FFP that is allowed to thaw overnight at 4C. It is literally the “cold” precipitate” of plasma Enriched source of Fibrinogen, VIII, vWF

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Cryoprecipitate

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  1. Cryoprecipitate Laura Cooling MD, MS Associate Medical Director Transfusion Medicine

  2. Cryoprecipitate • Prepared from FFP that is allowed to thaw overnight at 4C. It is literally the “cold” precipitate” of plasma • Enriched source of Fibrinogen, VIII, vWF • Contains thrombospondin, fibronectin, some IgM antibodies

  3. Cryoprecipitate Each unit • 7-15 cc total volume • 250 mg fibrinogen • 80-120 U VIII Adult: Pool several units (avg 10) for adults

  4. Indications for Cryoprecipitate • Hypofibrinogenemia (<100 mg/dL) and bleeding/prior to surgery • Dysfibrinogenemia and bleeding/prior to surgery • Factor XIII deficiency • Fibrin patch-Oto, cardiothoracic, dental • Uremic bleeding Less Common Now (better alternatives) • von Willebrand Disease, VIII deficiency

  5. Common Mistakes Inadequate dose • order 1 unit (10 cc) for adult Inappropriate Administration • Patient with volume overload and Multifactor deficiency (long PT/PTT) Over-ordering/ Over transfusion • Surgery responsible for 65% cryo waste

  6. Cryoprecipitate Administration • ABO compatible preferred but not required • Infused within 4 hrs of thaw, pooling Dose:10 pooled (adult) 1 unit/5 kg (infants/children) Rate: Like FFP (200-250 cc/20-30 min) Efficacy:Increase fibrinogen 5 mg/dl /unit 10 units=raise fibrinogen 50 mg/dl

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