1 / 10

Gleb Sukhorukov

Explore innovative technology of Layer-by-Layer encapsulation at the forefront of research impact, with versatile applications in Biomedical, Pharma, Cosmetic, Food, and Materials industries. Discover multifunctional microcapsules, Macromolecule encapsulation, and advanced applications like controlled release and cell targeting. Benefit from collaborative efforts and cutting-edge research activities focusing on biomedical applications, single-cell biopsy, cell communication, and more.

coonm
Download Presentation

Gleb Sukhorukov

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Micro- and Nanoencapsulation Laboratory St. Petersburg State Polytechnic University Gleb Sukhorukov /Queen Mary University of London, United Kingdom/

  2. Technology of Layer –by-Layer encapsulation (Max Planck Institute of Colloids and Interfaces) • >25 groups working in area of LbL encapsulations in Europe, USA, China, Japan, Singapore, Australia and worldwide • ~ 3,000 publications over 10 years • Reserach impact (high citation numbers) • Versatile applications (Biomedical, Pharma, Cosmetic, Food, Materials) • Strong industrial interest (Bayer AG, BASF, L‘Oreal, Nestle...) • Spin-off company Capsulution AG

  3. Multifunctionality to Microcapsules (50nm – 50 mkm) Microreactors Macromolecule encapsulation Visualization, Sensors A+B C Protection Cell-/Tissue-Targeting Controlled release Remote activation Magnetism • Most of activities are in: • Novel Phys/Chem properties; • Deliver systems; • Cell biology tool

  4. Delivering/Sensing Submarine External triggering / reporting inside cells/tissues Floating in body Submarine

  5. Perspective Research Activities at SPbSPU - BioMedical & BioPhysics • Single-cell biopsy/ Cell-to Cell communication • Capsule-Surface interactions • Fabrication of Release control over depot-systems • In vivo studies for encapsulated drugs delivery • and more…

  6. Single-cell biopsy / Cell-to-Cell Communication Capturing molecules intracellularly and delivery to other cells – artificial exosomes exchange Available expertise: Mass-Spec, Cell facilities Collaboration: Prof. M.Khodorkovskii Dr. Irina Nazarenko (Freiburg), Dr. Arkady Shipuline

  7. Capsule – Surface Interaction • One of major problems of LbL microencapsulation technology – aggregation and sticking to cell membranes when used in vivo. • Some coatings (PLL-g-PEG, Dextran) are proposed to cope with the problem, but are not absolute solution. Study adhesion aiming to optimize selectivity to cell surface Optical tweezers technique (M. Khodorkovski’s group) to measure interaction forces.

  8. Fabrication and Release control of depot-systems Fabrication and controlled gradual release from microcapsules and its assemblies as a depot-system. Monitoring on cell culture/ Tissue scaffolds . Modelling of Release kinetics

  9. Animal Testing and More…… We open for New Ideas on Other Areas! Partner for sample testing - St. Petersburg Institute of Vaccines and Sera Russian Ministry of Health

  10. Outlook / Key Performance Indicators In 2-3 years time: - 3-4 academic staff/postdocs, PhD students, master students • Publications (IF>3): • 1-2 (2015), 3-4 (2016, 2017..... and beyond) • Indusrial contracts and/or joint research grant (1-2 per year) • Research grants (RSF, ....EU, International) – 1 per year from 2016

More Related