1 / 13

Long- Term results of intravesical Hyaluronan therapy in BPS/IC

Long- Term results of intravesical Hyaluronan therapy in BPS/IC. Engelhardt et al., 2010. Hyaluronan Long- Term results. 70 pat. With BPS and HA therapy between 2001 and 2003 received a questionnaire (VAS) to evaluate the present status (at 2008)

cora
Download Presentation

Long- Term results of intravesical Hyaluronan therapy in BPS/IC

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Long-Termresults of intravesicalHyaluronantherapy in BPS/IC Engelhardt et al., 2010

  2. Hyaluronan Long-Termresults 70 pat. With BPS and HA therapybetween 2001 and 2003 received a questionnaire (VAS) toevaluatethepresent status (at 2008) Patientshadpreviously a highsymptomremisionrate at short-term (>80%)

  3. Hyaluronan Long-Termresults Results: 48/70 responded tothequestionnaire Mean follow-up of 4.9 years 8.15 beforetherapy VAS 2.71 aftertherapy (Short –term) 2.14 Long-term (after 5 years)

  4. Hyaluronan Long-Termresults 1) Patientsevaluation: 50% of patients (24/48) werestill free of bladdersymptoms at 5 y. follow-up, withoutanyadditionaltherapyaftertheinitialinstillation series

  5. Hyaluronan Long-Termresults 2) Patientsevaluation: 41.7% of patients (20/48) symptomsrecurredwithinthefirstyearafterinstillationtherapy. 25% were free of symptomsafterreceiving HA maintenancealone (12/48) 16.7% were free afterreceiving HA in combinationwith oral PPS (8/48)

  6. Hyaluronan Long-Termresults 3) Patientsevaluation: 8.3% of patients (4/48) no change of symptoms

  7. Hyaluronan Long-Termresults Conclusion: Besides a highrate of acutesymptomremision, Hyaluronanalso shows long-termefficacy in a considerable number of BPS patients, whatsuggeststhatsomepatientsmaybecuredbythistherapy

  8. Hyaluronan Long-Termresults VAS reduction: > 2 in 85.4% of patients (41/48) < 2 in 6.25% of patients (3/48) No improvement in 8.3% (4/48)

  9. Hyaluronan Long-Termresults Hyaluronanreinforcestheurine-tissuebarrierbyintegration in the GAG-layerontheluminalsurface and the base of urothelialcells, a part of otheractions, likethe anti-inflammatoryeffect Hyaluronanlong-termtherapy has no adverse effects and can beadministeredoveryearswithoutdisadvantageforthepatients

  10. Hyaluronan Long-Termresults Thehigh response rate in thepresentstudymaybe a consequence of patientselection and standardization of instillationtherapy ModifiedPotassium Test Easierapplicablecriteriafacilitates diagnosis, withearlierinitiation of therapy and betteroutcomes

  11. Hyaluronan Long-Termresults ThepatientsreceivedweeklyHyaluronaninstillationsuntilsymptoms resolved as topatientsjudgementorifinstillationtherapyturnedouttobeineffectiveafter a maximum of 10 instillations Instillationtherapywasonlyperformed in patientswhowereabletoretaintheinstillationfor 2 hours

  12. Hyaluronan Long-Termresults Thequestionnairewasidenticalbefore and afterthetherapy Averagenumber of instillations: 12

  13. Hyaluronan Long-Termresults Response rateafterinitialinstillationtherapywithother GAG substituents: 56% Heparin 45% Chondroitin sulfate 44% PPS Long-termresults do notexistforthesesubstances

More Related