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Microprosthetic Implant Implant for the Treatment of Erectile Dysfunction

Microprosthetic Implant Implant for the Treatment of Erectile Dysfunction. Matt Schwartz and Robert Douglas Advisor – Dr. Franz Baudenbacher. Thesis. A microprosthetic drug delivery implant has the potential to provide a biomimetic treatment option for erectile dysfunction.

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Microprosthetic Implant Implant for the Treatment of Erectile Dysfunction

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  1. Microprosthetic Implant Implant for the Treatment of Erectile Dysfunction Matt Schwartz and Robert Douglas Advisor – Dr. Franz Baudenbacher

  2. Thesis • Amicroprosthetic drug delivery implant has the potential to provide a biomimetic treatment option for erectile dysfunction. • Minimally invasive • Patient compliance • Targeted drug release and control

  3. Erectile Dysfunction Background • Erectile Dysfunction (ED) • Prevalence in men 40-70 = 52%1 • Current treatment options • Prescription oral pills • Injection therapy • Penile prosthetics • Drug therapy market size • $3.1 billion in 2005 • Estimated growth of 6.5% annually through 20102

  4. Pathophysiology • Physiology of erection • Erectile tissue – cavernous smooth muscles • Low blood flow in flaccid state • Stimulation causes arterioles to dilate3 • Neurophysiologoy • Cavernous nerves – neurovascular control of erection/detumescence • Dorsal nerve – sensory function • Pathology of ED • Psychogenic • Neurogenic • Estimated at 10-19% • Iatrogenic • Arteriogenic • Combination

  5. Problem and Solution • Diagnostics are expensive and inefficient • “There is a pressing need for new technologies for diagnosing and treating communicable and non-communicable diseases”1 • Benefits of syringe design • Parallel testing based on symptom and/or circumstance • Easy to administer • Disposable • Low power consumption (plunger driven flow) • Rapid and reliable results (MEMS) • Low cost

  6. Completed Work • Researched diseases and diagnostic assays • Investigated current technologies for blood filtration

  7. Ongoing Work • Design for proof of concept experiment • Filtration mechanism • Membrane • Nanofibers • Design specific mechanism • Single disease and assay selection • HIV – Immunoassay • Malaria – Immunochromatography • Cancer – Immunoassay (i.e. prostate specific antigen) • Compare efficiency of syringe to standard assay processes • Specificity • Sensitivity • Timing

  8. Future Work • Extend proof of concept results to further design • Calculate maximum possibilities for parallel testing • Explore avenues for prototype manufacturing

  9. Conclusions • Primary focus – Determining the most suitable test for proof of concept • Secondary focus – Designing filter for syringe implementation • Tertiary focus – Symptomatic, geographical, and situational based diagnostic groupings • d

  10. References • Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. Urology 1994; 151: 54-61. • Elder, Melissa. Men’s Health: The Worldwide Market for Current and Emerging Drug Therapies, 2nd ed. Kalorma Information. May 2006. • Robert C. Dean, MD and Tom F. Lue, MD. Physiology of penile erection and pathophysiology of erectile dysfunction. UrolClin North Am. 2005 November; 32(4): 379-v.

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