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Hematopoietic Stem Cells

Hematopoietic Stem Cells. Multipotent Hematopoietic Stem Cell- A stem cell that differentiates into any of the blood cells . Used most. Multipotent vs. Pluripotent Which is better?. What are hematopoietic stem cells made of?. Lymphocyte-biased HSC’s (Ly-bi)

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Hematopoietic Stem Cells

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  1. Hematopoietic Stem Cells • Multipotent • Hematopoietic Stem Cell- A stem cell that differentiates into any of the blood cells. • Used most.

  2. Multipotent vs. PluripotentWhich is better?

  3. What are hematopoietic stem cells made of?

  4. Lymphocyte-biased HSC’s (Ly-bi) • High L/M ratio. Lymphocytes >10. • 2. Myeloid-biased HSC’s ( • 3. Balanced HSC’s (Bala) • Lymphocytes > or = 3 and < or = 10

  5. What are some Hematopoietic Stem Cell sources?

  6. Bone Marrow • Where is it found most? • Extraction • How is it Maintained? • First Bone Marrow Transplant

  7. Peripheral Blood • Hormone Growth Factors. • How are they extracted? • Peripheral Blood Machine • How are they maintained?

  8. Umbilical Cord Blood • Percentage, first transplant. • Where? • Benefit

  9. Which Source is Best? • Bone Marrow Pros • Bone Marrow Cons • Peripheral Blood Pros • Peripheral Blood Cons • Umbilical Cord Blood Pros • Umbilical Cord Blood Cons

  10. Leukemia • Disease of White blood cells • Results when cells function abnormally • Interfere with other organs • Five stages of severity • Two main types, chronic and acute. • Why are hematopoietic Stem cells used as opposed to another type?

  11. Curing Leukemia via Stem Cell Transplant • 1. Need a perfect donor • 2. Destroy Immune System by chemotherapy and radiation. • 3. Stem cell transplant from one of the three sources. • The hematopoietic stem cells start making new blood cells and fix the immune system. • Make a complete new one without abnormal cells.

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