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口 腔 病 理 科

口 腔 病 理 科. Salivary gland-embryology 唾液腺 - 胚胎學. 陳玉昆副教授 : 高雄醫學大學 口腔病理科 07-3121101~2755 yukkwa@kmu.edu.tw. 學 習 目 標. 參考資料. References. Avery JK. Oral development and histology. 2 nd edition, Chapter 21, p. 352-81

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口 腔 病 理 科

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  1. 口腔病理科 Salivary gland-embryology 唾液腺-胚胎學 陳玉昆副教授: 高雄醫學大學 口腔病理科 07-3121101~2755 yukkwa@kmu.edu.tw

  2. 學 習 目 標 參考資料 References • Avery JK. Oral development and histology. 2nd edition, Chapter 21, p. 352-81 • Avery JK. Oral histology-a clinical approach. 1st edition, Chapter 15, p. 184-95 • Berkovitz BK, Holland GR, Moxham BH. 2nd edition, p.215, 220 4. de Almeida PDV, et al.. Saliva Composition and Functions: A Comprehensive Review. J Contemp Dent Pract 2008 3:72-80 5. Kaohsiung Medical University, Oral Pathology Department 1.Origins of salivary gland 2.Stages of development 3.Differentiation of terminal tubule cells 4.Cleft formation during salivary gland branching 5.Factors affecting branching of salivary gland cell cords 6.Classification of salivary gland cell cords 7.Classification, innervation, anatomy of major salivary gland 8.Classification, anatomy of minor salivary gland 9.Ductal system - components, comparison, histology 10.Saliva – composition, function

  3. Frontal section through developing face Minor gland: 12 prenatal weeks Nasal septum Epithelial outgrowth of buccal epithelium invading the underlying mesenchyme 6th prenatal week Parotid bud Tongue 8th prenatal week 7th prenatal week Sublingual bud Submandular bud Ref: 1 Origins of salivary gland

  4. Bud formation Stages of development Stage I Ref: 1

  5. Stages of development Stage II Cord growth Ref: 1

  6. Stage III Branching of cord Stages of development Ref: 1

  7. Stage IV Lobule formation Stages of development Ref: 1

  8. Stages of development Stage V Canalization of cords to form ducts Ref: 1

  9. Lobule of gland Connective tissue septa Stages of development Ref: 2

  10. Stage VI Cytodifferentiation Stages of development Ref: 1

  11. Acinar cells Proacinar cell Terminal tubule cell (Stem cell) Intercalated duct cell Differentiation of terminal tubule cells

  12. Generalized cell proliferation No branching Hyaluronidase Digest the collagen Basal lamina Collagen Branching Factors affecting branching of salivary gland cell cords Ref: 1

  13. A B C M BM E M = messenchyme BM = basement membrane E = epithelium Type IV Type III Type I Collagen Type Cleft formation during salivary gland branching Ref: 1

  14. Tubuloacinar type Tubular Branching duct Tubulo- acinar Main duct Exocrine - duct system for secretion transportation Grape-like acinar Classification of salivary gland cell cords Ref: 1

  15. Merocrine type secretory process Discharge Method of secretory production Membrane Secretory granule Golgi Classification of salivary gland cell cords Ref: 1

  16. Location Capsule Size Parotid gland (14-28g) Subman- dibular gland (7-8g) Sublingual gland (3g) Classification- major salivary gland Ref: 1

  17. Stensen’s duct (7 cm long) Bartholin’s duct (Rivinus’s ducts) Warthin’s duct (5 cm long) Anatomy - major salivary gland Ref: 2

  18. Classification- major salivary gland Type of secretion Contribution of saliva Striated duct intercalated duct % Paro- tid gland % Subman- dibular gland Sublin- gual gland % Refs: 1, 4

  19. Sympathetic innervation Parasympathetic innervation Preganglionic Postganglionic Parotid gland Submandinular gland Sublingual gland Classification - major salivary gland Ref: 1

  20. Superior salivary nucleus Auriculotemporal n Parotid gland Otic ganglion Inferior salivary nucleus Chorda tympani Sublingual gland Superior cervical ganglion Submandibular ganglion Submandibular gland Innervation of salivary gland Parasympathetic VII IX Sympathetic Ref: 1

  21. Anatomy- major salivary gland Facial nerve vs fetal parotid gland Ref: 1

  22. Blood supply Arterial Venous Parotid gland Submandinular gland Sublingual gland Classification- major salivary gland Ref: 1

  23. Uncapsulated; named by location Anatomy - minor salivary gland Ref: 2

  24. Name Location Type of secretion Classification- minor salivary gland Contribution of saliva : 5-10% Ref: 1

  25. Classification- minor salivary gland Taste buds Taste buds Taste buds A A A: Small serous glands of von Ebner empty into the base of trench Circumvallate papillae in longitudinal Ref: 3

  26. Ductal system Acinus Secretory Units Intercalated Striated Capsule Ducts Excretory Septa Lobe Ref: 3

  27. Ductal system Mucous cell Intra-Lobular Inter-Lobular Myoepithelial cell Mucous acinus Striated duct Excretory duct Intercalcated duct Serous demilune Serous cell Ref: 3

  28. Oral cavity Major salivary gland duct orifice Oral epithelium Excretory duct Interlobular duct system Intralobular duct system Ductal system Serous acinus Mucous acinus Mixed acinus Ref: 2

  29. Relative ductal length Parotid gland Intercalated Submandinular gland Striated Sublingual gland Excretory Key Intercalated duct: P > M > L Striated duct: M > P > L Comparison of ductal system Ref: 1

  30. Mixed acini Striated duct Serous demilune Intercalated duct Myoepithelial cells Excretory duct Mucous acini Histology of ductal system 2 1 Ref: 1

  31. Mixed alveolus Serouis demilune Serous alveolus Mucous alveolus Histology of ductal system Ref: 2

  32. Histology of ductal system Ref: 2

  33. Histology of ductal system Ref: 2

  34. Myoepithelial cell Mucous cell Myoepithelial cell Histology of ductal system Ref: 2

  35. Histology of ductal system Intercalated duct Adipose tissue Serous acini Myoepithelial cell Excretory duct Ref: 5

  36. Histology of ductal system Mucous acini Mixed acini Serous acini Myoepithelial cell Striated duct Ref: 5

  37. Intralobular duct Blood vessel Histology of ductal system Ref: 2

  38. Scanning electron microscope Myoepithelial cell processes Histology of ductal system Ref: 2

  39. Serous cell Mucous cell Histology of ductal system Ref: 2

  40. Composition of saliva ml Ref: 1

  41. Composition of saliva Ref: 2

  42. Composition of saliva Ref: 2

  43. 1 2 3 5 4 6 Function of saliva 3 pints = ? liter Ref: 2

  44. Function of saliva Ref: 2

  45. Function of saliva Refs: 2, 4

  46. Function of saliva Ref: 2

  47. Summaries Knowing: 1.Origins of salivary glands 2.Stages of development 3.Differentiation of terminal tubule cells 4.Cleft formation during salivary gland branching 5.Factors affecting branching of salivary gland cell cords 6.Classification of salivary gland cell cords 7.Classification, innervation, anatomy of major salivary gland 8.Classification, anatomy of minor salivary gland 9.Ductal system - components, comparison, histology 10.Saliva – composition, function

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