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Figure 1. A. GBM lines:. 5 6 8 10 12 14 15 16 22 26 28 34 36 38 39 43 44 46 58 59. p16. Cdk4. Cdk6. β -actin. B. GBM lines:. 5 6 8 10 12 14 15 16 22 26 28 34 36 38 39 43 44 46 58 59. CDKN2B (p15). CDKN2A (p16). CDKN2C (p18). CDKN2D (p19). β -actin. GBM5. +4. +4. GBM5. GBM5.

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5 6 8 10 12 14 15 16 22 26 28 34 36 38 39 43 44 46 58 59

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  1. Figure 1. A. GBM lines: 5 6 8 10 12 14 15 16 22 26 28 34 36 38 39 43 44 46 58 59 p16 Cdk4 Cdk6 β-actin B. GBM lines: 5 6 8 10 12 14 15 16 22 26 28 34 36 38 39 43 44 46 58 59 CDKN2B (p15) CDKN2A (p16) CDKN2C (p18) CDKN2D (p19) β-actin

  2. GBM5 +4 +4 GBM5 GBM5 GBM5 +2 +2 CDK4 CDK4 CDK4 CDK4 +1 +1 0 0 Log2 (ratio) Log2 (ratio) Log2 (ratio) Log2 (ratio) -1 1 - -2 2 - -4 4 - 55.4 Mb 55.4 Mb 55.4 Mb 55.4 Mb 55.8 Mb 55.8 Mb 55.8 Mb 55.8 Mb 56.3 Mb 56.3 Mb 56.3 Mb 56.3 Mb 56.8 Mb 56.8 Mb 56.8 Mb 56.8 Mb Base Position Base Position Base Position Base Position GBM22 +4 +4 +4 GBM22 GBM22 +2 +2 +2 +1 +1 +1 Log2 (ratio) Log2 (ratio) Log2 (ratio) 0 0 0 1 1 1 - - - 2 2 2 - - - CDK4 CDK4 CDK4 4 4 4 - - - 55.4 Mb 55.4 Mb 55.4 Mb 55.4 Mb 55.4 Mb 55.4 Mb 55.4 Mb 55.8 Mb 55.8 Mb 55.8 Mb 55.8 Mb 55.8 Mb 55.8 Mb 55.8 Mb 56.3 Mb 56.3 Mb 56.3 Mb 56.3 Mb 56.3 Mb 56.3 Mb 56.3 Mb 56.8 Mb 56.8 Mb 56.8 Mb 56.8 Mb 56.8 Mb 56.8 Mb 56.8 Mb Base Position Base Position Base Position GBM34 +4 +4 +4 GBM34 GBM34 GBM34 GBM34 +2 +2 +2 CDK6 CDK6 CDK6 CDK6 CDK6 +1 +1 +1 0 0 0 Log2 (ratio) Log2 (ratio) Log2 (ratio) Log2 (ratio) Log2 (ratio) 1 1 1 - - - 2 2 2 - - - 4 4 4 - - - 90.1 Mb 90.1 Mb 90.1 Mb 90.0 Mb 90.0 Mb 90.0 Mb 91.9 Mb 91.9 Mb 91.9 Mb Base Position Base Position Base Position Base Position Base Position Figure 2. A B C

  3. Figure 2. D K Reference STOP GBM28 A193T

  4. Figure 3. A. B.

  5. Figure 4.

  6. Figure 5. A GBM34 0 0.01 0.03 0.1 0.3 1 PD0332991, microM p-Rb Rb B GBM43 0 0.01 0.03 0.1 0.3 1 PD0332991, microM p-Rb Rb C GBM5 0 0.01 0.03 0.1 0.3 1 PD0332991, microM p-Rb Rb

  7. GBM lines 61 63 64 66 p16 Cdk4 β-actin Figure 6. A. B.

  8. Figure 6. C. D. PD0332991, microM 0 0.01 0.03 0.1 0.3 1 p-Rb Rb

  9. Figure 7. A. P < 0.01

  10. Figure 7. B. Placebo PD0332991 Ki67 p-Rb ** **

  11. Figure 8.

  12. Supplemental figure 1 A. Cdk4 shRNAs pLKO.1 1 2 Cdk4 p-Rb β-actin B.

  13. Supplemental figure 2

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