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MLH1 Mutations and the Formation of Hereditary Non-Polyposis Colon Cancer(Lynch Syndrome)

MLH1 Mutations and the Formation of Hereditary Non-Polyposis Colon Cancer(Lynch Syndrome). Kevin Harris. Some Families are Predisposed to Colon Cancer. What Genes Cause HNPCC?. MLH1 Encodes a DNA Mismatch Repair Protein. Meiotic Pachytene Arrest is Observed in MLH1-Deficient Mice.

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MLH1 Mutations and the Formation of Hereditary Non-Polyposis Colon Cancer(Lynch Syndrome)

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  1. MLH1 Mutations and the Formation of Hereditary Non-Polyposis Colon Cancer(Lynch Syndrome) Kevin Harris

  2. Some Families are Predisposed to Colon Cancer

  3. What Genes Cause HNPCC?

  4. MLH1 Encodes a DNA Mismatch Repair Protein

  5. Meiotic PachyteneArrest is Observed in MLH1-Deficient Mice

  6. MLH1 Mutants Lack MLH1 Protein and Make Many Replication Errors

  7. Molecular Markers Confirm MLH1 Mutations in HNPCC Patients

  8. Familial Non-Polyposis Colon Cancer (Lynch Syndrome) Leads to Other Cancers

  9. FAP HNPCC Polyps Come in Many Forms

  10. With HNPCC Additional Screening Visits are Necessary

  11. A Preemptive Strike Against Cancer

  12. http://www.hopkins-gi.org/GDL_Disease.aspx https://humana-portal.dnadirect.com/content/physician-site/hereditary-nonpolyposis-colorectal-cancer/index.html http://www.sciencedirect.com/science/article/pii/S1471491402023596 Edelmann, Winfried. "Meiotic Pachytene Arrest in MLH1-Deficient Mice." Cell 85.7 (1996): 1125-134. Print. Pena-Diaz, Javier, and Josef Jiricny. "Mammalian Mismatch Repair: Error Free or Error Prone." Trends in Biochemical Sciences 37.5 (2012): 206-14. Print. http://www.cancernetwork.com/display/article/10165/106278 http://www.gastrolab.net/ng030.htm http://www.ajronline.org/content/186/6/1611.figures-only http://my.clevelandclinic.org/disorders/inherited_colon_cancer/dd_hnpcc.aspx http://www.gen.vcu.edu/GRADUATE/GeneticCounseling Sources

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