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Cand1 displacement

Cand1. Cand1. Cul1. Cul1. Rbx1. Rbx1. Nedd8. Skp1. Nedd8. P. P. Jab1. MIF. Cul1. Cdc25A/C. Rbx1. CSN. SCF. P. E2F1. P. DP1. Proteasome. P. p27. A. DNA damage, stalled replication. ATR. ATM. Signal transduction. Chk1. Chk2. Target modification: phosphorylation

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Cand1 displacement

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  1. Cand1 Cand1 Cul1 Cul1 Rbx1 Rbx1 Nedd8 Skp1 Nedd8 P P Jab1 MIF Cul1 Cdc25A/C Rbx1 CSN SCF P E2F1 P DP1 Proteasome P p27 A DNA damage, stalled replication ATR ATM Signal transduction Chk1 Chk2 Target modification: phosphorylation ubiquitination Target destruction B “Inactive SCF complex” Neddylation of Cul1 Cand1 binding Skp1 Cul1 F-box Rbx1 Deneddylation of Cul1 by Jab1/CSN5 Cand1 displacement F-box “Active SCF complex”

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