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When One is Not Enough: Randomisation by Community. Neal Alexander. Why randomise by community or cluster Historical development of cluster-randomised trials Emphasis on infectious diseases Recent and current contributions of TEG. Outline.
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When One is Not Enough:Randomisation by Community Neal Alexander
Why randomise by community or cluster Historical development of cluster-randomised trials Emphasis on infectious diseases Recent and current contributions of TEG Outline
Rationale: some interventions are difficult or impossible to allocate or assess individually Freeman et al 2012 TMIH
Ferebee et al (1963): isoniazid prophylaxis in mental institutions
Management of STDs for HIV (Grosskurth et al 1995)
Cluster Hostels Mine shaft • Compares: • community-wide isoniazid preventive therapy vs • standard of TB care • 1ary endpoint: TB incidence over 12 months • Results unveiled at CROI 2012 by Fielding & Churchyard
Design & Analysis of Trials to Compare Genetic Selection Coefficients
Spatial Analysis of ‘Spillover’ km Anaya-Izquierdo et al in prep; trial in Kroeger et al BMJ 2002