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Hormonal Response in Delayed Puberty and Hypogonadotropic Hypogonadism

This study explores the differential response of LH and FSH in patients with delayed puberty and hypogonadotropic hypogonadism before and after Clomiphene citrate administration. Results show significant changes in hormone levels post-treatment.

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Hormonal Response in Delayed Puberty and Hypogonadotropic Hypogonadism

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  1. Differential Response of Serum LH, FSH in Hypogonadotropic Hypogonadism and Delayed Puberty in LH-RH Stimulation before and after Clomiphene citrate Administration Dr. Samira Asfoura

  2. Normal Range: FSH: 1.3 -22.2 IU/L LH: 1.92 -9.38 IU/L Testosterone : 8.1 - 30.3 nmol/L Prolactine: 56.8 -386.6 IU/L

  3. 9 patients Delayed puberty LH FSH Response of LH-RH 14.74 ±7.17 IU/L IU/L IU/L IU/L Response of LH-RH Response of LH-RH Response of LH-RH 8.03 ± 4.56 7.31 ± 3.37 4.64 ± 3.07 0.84 ± 0.45 1.30 ± 1.56 0.91 ± 0.55 1.43 ± 1.89 After Clomiphene Before Clomiphene After Clomiphene Before Clomiphene Pvalue= 0.01 Pvalue= 0.04

  4. 6 patients Hypogonadotropic hypogonadism FSH LH Response of LH-RH Response of LH-RH Response of LH-RH Response of LH-RH IU/L IU/L IU/L IU/L 8.86 ± 3.85 6.49 ± 1.73 5.09 ±2.95 3.59 ± 1.25 0.71 ± 0.45 0.56 ± 0.42 0.67 ± 0.51 0.54 ± 0.40 After Clomiphene Before Clomiphene After Clomiphene Before Clomiphene Pvalue= 0.04 Pvalue= 0.004

  5. Thank You For Your Listening

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