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UV light, Disinfectants, Antibiotics

UV light, Disinfectants, Antibiotics. UV light is used to control microbial growth Adjacent thymine molecules DNA cross link to form thymine dimer This leads to mutations during the replication of DNA #3 – growth , UV light cannot penetrate plastic.

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UV light, Disinfectants, Antibiotics

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  1. UV light, Disinfectants, Antibiotics

  2. UV light is used to control microbial growth • Adjacent thymine molecules DNA cross link to form thymine dimer • This leads to mutations during the replication of DNA • #3 – growth , UV light cannot penetrate plastic.

  3. Disinfectants – antimicrobial agents used on objects – floors. Lysol • Antiseptics – antimicrobial agents used on living tissue – mouthwash. Listerine • They inactivate enzymes • Zone of inhibition – in general larger the zone of inhibition more effective is the antimicrobial agent

  4. Gram negatives are more resistant than gram positives. • Substances cannot penetrate the outermembrane.

  5. Antibiotics • Made by microbes • Purified by the pharmaceutical companies • Penicillin • Mold – Penicillium notatum • Inhibits the formation of peptidoglycan • G- - resistant • G+ - sensitive

  6. Penicillin – selectively toxic to bacteria. In general, it is not toxic to the host (humans) • Humans have no peptidoglycan

  7. Chloramphenicol – Streptomyces • Inhibits protein synthesis on the 70S ribosomes • High concentrations and prolonged use can cause aplastic anemia • Streptomyces • Tetracycline, Streptomycin, erythromycin • Erythromycin – cannot penetrate the outer membrane

  8. Gentamicin – Micromonospora • Inhibits protein synthesis on the 70S ribosomes. • Sulfanilamide – synthetic drug • Inhibits folic acid synthesis

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