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. 2. Chlamydia: Urethritis, Lymphogranuloma venereum3. Protozoa: Trichomonas vaginalis4. Fungal: Candida albicans5. Parasite: Acarus scabeii---- Scabeis Phthirus pubis----Pediculosis6. Viruses: HPV------- Genital warts HSV---- Genital herpes simplex
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1. Sexually Transmitted Diseases Causative Agents:
1.Bacterial:
A. Spirochetes: Treponema pallidum
B. Nesseria gonorrhea: Gonorrhea
C. Haemophilus Ducreys: Chancroid
D. Donovan granulomais: Granuloma
inguinale
2. 2. Chlamydia: Urethritis, Lymphogranuloma venereum
3. Protozoa: Trichomonas vaginalis
4. Fungal: Candida albicans
5. Parasite: Acarus scabeii---- Scabeis
Phthirus pubis----Pediculosis
6. Viruses: HPV------- Genital warts
HSV---- Genital herpes simplex
Pox virus ------ Molloscum contagiosum
HIV ------- AIDS
HBV --------- Hepatitis
3. Clinical Presentations 1. Itching: scabies, pediculosis,
trichomoniasis, candidiasis
2. Genital ulcer:
Primary syphilis.
Cutaneous manifestations of secondary syphilis.
Herpes progenitalis.
Chancroid.
Gummatous Ulceration of tertiary syphilis.
Lymphogranuloma venereum
granuloma Inguinale .
4. 3. Papulonodular lesions:
a. venereal warts ”Condylomata
accuminata”
b. Molloscum contagiosum
c- Condylomata lata
4. Discharge: urethral or vaginal discharge
5. Systemic manifestations: Syphilis, Reiters syndrome, AIDS, Hepatitis
5. Urethral DischargeGonorrhea Neisseria gonorrhoeae: Gram-negative diplococci - coffee bean
The target organs: urethra, cervical mucosa, pharynx, conjuctiva or anorectum
Mode of Transmission
Incubation Period: 2-5 days
6. Clinical Features I. Males:
Comlications:
1. Tysons gland infection: both sides of freulum of penis
2. Litters gland infection: Periurethral abscess
3. Cowpers glands infection: base of prostate
4. Acute prostatis
5. Chronic prostatis
6. vesiculitis, epidedymitis, epidedymoorchitis
7. Cystitis
8. Disseminated gonococcal infestion
7. II. Females:
Comlications:
1. Skenes glands infection: periurethal abscess or urethral stricture
2. Bartholin gland infection: cyst
3. Pelvic inflammatory disease: infertility
8. Extragenital Gonorrhea 1. Proctitis
2. Ophthalmia neonatorum
3. Mouth and throat: pharyngitis
4. Disseminated gonococcal infection: arthriris, Tenosynovitis, endocarditis, meningitis, skin lesions
9. Diagnosis 1. History
2. Urethral or endocervical smear
3. Two- glass urine test
4. Two- catch urine test
5. Culture: "chocolate" agar, Thayer-Martin medium
6. Oxidase test and sugar utilization test
10. Treatment - treatment of partner
- combined infection is common
Single-Dose regimen: in uncomplicated gonorrhea
Ceftriaxone 125 mg – i.m. injection
Cefixime 400 mg- oral
Ofloxacin 400 mg- oral
Ciprofloxacin 500 mg- oral
Levofloxacin 250 mg- oral
Spectinomycin- 2gm
Kanamycin- 2gm
Cefotaxime- 500 mg
11. In Disseminated gonococcal infection:
The above drugs given 2-3 times/days for 3-10 days according to site and response
Multiple dose regimen:
Tetracycline 250mgX4 for 10 days
Doxycycline 100mgX2 for 10 days
Metheprim tablets 2X2 for 10 days
12. Non- Gonococcal urethritis 1. Chlamydia trachomatis 50%
2. Bacteria: E. coli, Klebsiella, Proteus, Haemophilus vaginalis, ureaplasma urealyticum, intraurethaurethral chancre.
3. Viral: intraurethral H. simplex or wart
4. Protozoal: trichomonas vaginalis
5. Fungal: candidiasis
6. Stricture
7. Food and drug allergy
8. Chemical: strong detergents
9. True non- pecific urethritis
13. Chlamydial urethritis The incubation period
Clinical features:
1. in males: shower sign
2. in females: cervicitis or PID
Diagnosis:
1. History
2. urethral or cervical smear
3. Culture
4. Serological test
14. Treatment Azithromycin 1 gm orally as single dose
Doxycycline 100 mg twice daily for 7 days
Tetracycline 500mg X4 for 7 days
Erythromycin 500mg X4 for 7 days