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Birth Certificate data is crucial for medical research. Reproductive Health Report Card. The Problem. Rates of congenital anomalies and prematurity haven’t changed in 30 years Science has failed the pregnant woman!. The Birth Certificate as an information hub.
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The Problem • Rates of congenital anomalies and prematurity haven’t changed in 30 years • Science has failed the pregnant woman!
The Birth Certificate as an information hub • Birth Certificate • low birth weight • prematurity • Infant Death Certificate • All causes of children’s diseases
The Birth Certificate as an information hub • Birth Certificate • low birth weight • prematurity • Birth Defects Registry • Structural congenital anomalies • Infant Death Certificate • All causes of children’s diseases
The Birth Certificate as an information hub • Birth Certificate • low birth weight • prematurity • Birth Defects Registry • Structural congenital anomalies • Infant Death Certificate • All causes of children’s diseases • National Death Index • Deaths among pregnant women
The Birth Certificate as an information hub • Pregnancy Blood Samples • Exposures in mom • Birth Certificate • low birth weight • prematurity • Birth Defects Registry • Structural congenital anomalies • Infant Death Certificate • All causes of children’s diseases • National Death Index • Deaths among pregnant women
Discovering Causes Through Bio-Research • California Birth Defects Monitoring Program banks blood samples on 100,000 pregnant women per year. • As of June 2006, we have banked 290,000 pregnant women’s blood samples.
Discovering Causes Through Bio-Research • Each sample is split into two serum specimens stored at -70°C and one clot stored at -20°C. • Samples are banked at Long Beach Memorial Medical Center, Long Beach, California.
Discovering Causes Through Bio-Research • Pregnancy blood samples are collected between 15-19 weeks • Urban, rural, multi-racial and socioeconomically diverse population
Discovering Causes Through Bio-Research • Childhood diseases that can be studied with blood samples: Birth defects • Mental retardation • Low birth weight • Prematurity • Childhood cancer • Autism
Discovering Causes Through Bio-Research • Risk factors that can be studied with blood samples: Medications • Infections • Chemicals Diet • Lifestyle • Genetic
Pregnancy Blood Samples • Exposures in mom • Birth Certificate • low birth weight • prematurity • Birth Defects Registry • Structural congenital anomalies • Infant Death Certificate • All causes of children’s diseases • National Death Index • Deaths among pregnant women
Summary • We need to find causes of children’s diseases
Summary • We need to find prenatal antecedents of adult diseases
Summary • To do this we need to link birth certificate data with pregnancy blood samples and health outcomes among children and adults