State of BER September 5, 2008

1. Biological and Environmental Research State of BERSeptember 5, 2008 Anna Palmisano, Ph.D. Associate Director of Science Biological and Environmental Research

2. Biological and Environmental Research Outline of Talk • Reorganization and Personnel • Retreat – “Re-discovering BER Science” • Budget & Transition Planning IV. Science Focus Areas V. News from the Divisions VI. BERAC Activities: Looking Ahead…

3. My Priorities for BER • Rebuilding the leadership team after a number of retirements • Building even stronger programs through strategic planning and scientific peer review processes • Encouraging linkages among programs – cross-cutting themes • Delivering on investments—post-award management • Strengthening partnerships within SC, DOE, and Federal Government • Empowering program managers to develop and sustain national programs that provide world leadership • Telling the BER “story” – clearly articulating BER science, increasing visibility of our successes

4. Biological and Environmental Research Drivers for BER Re-organization • Improve communication among employees • Reduce “stove-piping” • Allow full participation of all employees in programs • Reflect mission priorities and approach • Position BER for the future

5. Previous BER Organization: Office of Biological & Environmental Research Associate Director Office Staff Contacts Sr. Technical Advisor Michael Riches Chief Scientist David Thomassen Anna Palmisano Associate Director Kathy Holmes, Administrative Specialist Climate Change Research Division Mike Kuperberg, Acting Environmental Remediation Sciences Division Paul Bayer, Acting Life and Medical Sciences Division David Thomassen, Acting Kirin Alapaty Jeff Amthor Anjuli Bamzai Karen Carlson-Brown Roger Dahlman Wanda Ferrell Rick Petty Leslie Runion Robert Vallario Ashley Williamson Todd Anderson Teresa Jones Mike Kuperberg Kim Laing David Lesmes Sharon Betson Dean Cole Joanne Corcoran Dan Drell Patrick Glynn Joseph Graber, AAAS Scholar Susan Gregurick Roland Hirsch John Houghton Arthur Katz Peter Kirchner (IPA) Noelle Metting Prem Srivastava Marvin Stodolsky Michael Teresinski Sharlene Weatherwax Elizabeth White

6. BER Organization - People Office of Biological & Environmental Research Anna Palmisano Associate Director Kathy Holmes, Administrative Specialist Associate Director Office Staff Michael Riches,Sr. Technical Advisor David Thomassen, Chief Scientist Biological Systems Science Division Roland Hirsch , Acting Director Climate and Environmental Sciences Division Mike Kuperberg, Acting Director Kirin Alapaty Jeff Amthor Todd Anderson Anjuli Bamzai Paul Bayer Karen Carlson-Brown Roger Dahlman Wanda Ferrell Kim Laing David Lesmes Rick Petty Leslie Runion Robert Vallario Ashley Williamson Dean Cole Joanne Corcoran Dan Drell Patrick Glynn Joseph Graber Susan Gregurick Roland Hirsch John Houghton Terry Jones Arthur Katz Peter Kirchner (IPA) Noelle Metting Prem Srivastava Marvin Stodolsky Michael Teresinski Sharlene Weatherwax Elizabeth White 6

7. Office of Biological & Environmental Research: Programs Biological Systems Science Division Genomics: GTL Bioenergy Research Centers Joint Genome Institute Low Dose Radiation Biology Radiochemistry, Imaging & Instrumentation Structural Biology Carbon Sequestration Climate and Environmental Sciences Division Climate Change Research ARM Facility Environmental Remediation Science Program Environmental Molecular Science Lab Carbon Sequestration 7

8. Biological and Environmental Research Personnel Changes and Challenges • Biological Systems Science Division: • Finalizing recruitment action for permanent Division Director • Dr. Joe Graber hired as DOE Program Manager • Recruiting for IPA in Plant Sciences • Sharon Betson moved to Safety, Security and Infrastructure; Terry Jones is now Secretary for BSSD • Climate and Environmental Sciences Division: • Acting Division Director is currently Mike Kuperberg; Wanda Ferrell will begin acting on September 8 • Recruitment deferred until after transition • Recruiting for IPA in Climate Modeling

9. Biological and Environmental Research Retreat: “Re-discovering BER Science”

10. Biological and Environmental Research Goals of Science Retreat • Define BER mission, approach, cross-cutting themes • Share information across program boundaries • Team and establish linkages among programs • Introduce logic models as a consistent approach to strategic planning • Discuss managing risk, strategic partnerships, outreach and communication, human capital

11. Biological and Environmental Research Mission-Inspired Science BER advances world-class biological and environmental research programs and scientific user facilities to support DOE’s energy, environment, and basic research missions.

12. Biological and Environmental Research BER Mission Priorities • Develop biofuels as a major secure national energy resource • Understand relationships between climate change and Earth’s ecosystems, and assess options for carbon sequestration • Predict fate and transport of subsurface contaminants • Develop new tools to explore the interface of biological and physical sciences

13. Biological and Environmental Research The BER Approach • Understanding complex biological and environmental systems across many spatial and temporal scales: From the sub-micron to the global, from individual molecules to ecosystems, from nanoseconds to millennia. • Integrating science with tight coupling between theory, observations, experiments, and models • Supporting interdisciplinary research to address critical National needs • Engaging national laboratories, universities, and the private sector to generate the best possible science

14. BER Systems Science: Identify Key Components and Understand Interactions which Control System Response Multicellular Organisms Microbes Molecules Global Climate Ecosystems Enabling Science, Technologies, Facilities and Research Sites

15. Logic Model Approach to Strategic Planning 2 3 5 6 4 1

16. Biological and Environmental Research Outcome for BER Science • Achieve a predictive understanding of complex biological, climate and environmental systems in support of DOE’s Energy and Environmental Missions

17. Biological and Environmental Research Support Staff Retreat • Analyze process flow • Improve efficiency of operations • Re-balance workload • Encourage staff development activities

18. Biological and Environmental Research BER Budget Profile

19. Biological and Environmental Research Transition Planning: “Managing Uncertainty” • We are already preparing for, and will be implementing, the transition to a new administration • In FY 2009, we are planning for one or more Continuing Resolutions that may last the entire year, effectively freezing budgets at FY 2008 level • Expectations for a final FY 2009 Congressionally Appropriated Budget are unknown

20. Biological and Environmental Research Scientific Focus Areas (SFAs) for Labs: Implementing A New Management Approach • Todd Anderson and his team leading implementation of SFA’s for managing research at the DOE National Labs • SFA’s encourage integrative, collaborative research programs, in support of DOE mission • SFA’s take advantage of unique National Lab strengths in interdisciplinary, team-oriented, mission relevant research • The SFA’s will enhance dialogue between National Lab science managers and BER program managers • Best management practices developed and shared with the National Labs; follow up conference calls

21. Biological and Environmental Research Biological Systems Science Division: Updates

22. Biological and Environmental Research Biological Systems Science Division National Synchrotron Light Source II (NSLS-II) Imaging and Spectroscopy Workshop (POC: Roland Hirsch) • September 12, Washington, D.C. • Goal: To explore NSLS II imaging and spectroscopy applications for: • Microbiology • Cellular and organismal biology • Plant Science • Diagnostic Medicine • Life science applications for macromolecular crystallography and x-ray scattering are well defined…. • However, applications of planned imaging and spectroscopy are less clear and will be focus of workshop

23. Biological and Environmental Research Biological Systems Science Division • Bioenergy Research Center Reviews (POC: Patrick Glynn) • Year-end, on-site reviews of science and management by a team of experts • Plant sciences, microbiology, enabling technologies, computation and informatics, management, ES&H • Great Lakes Bioenergy Research Center: Sept 23-24, Madison, WI • Joint BioEnergy Institute: Sept 28-30, Emeryville, CA • BioEnergy Science Center: October 14-15, Oak Ridge, TN

24. Biological and Environmental Research Biological Systems Science Division • Workshop on Sustainability of Biofuels: State of the Science and Future Directions (POC: John Houghton, Libby White) • October 28-29 in Bethesda, MD • Goal: Assess the current state of the science and identify future research, opportunities for partnering • Jointly sponsored by DOE (SC/BER) and USDA (Research, Education and Economics, and US Forest Service) • Both Under Secretary Orbach and Under Secretary Buchanan will attend • Co-led with Phil Robertson of GLBRC, Sustainability Thrust Leader

25. Biological and Environmental Research Biological Systems Science Division Workshop on New Frontiers of Science in Radiochemistry and Instrumentation for Radionuclide Imaging (POC: Prem Srivastava) • November 4-5, Bethesda, MD • Goal is to discuss reconfiguration of the BER Radiochemistry and Instrumentation program to incorporate research relevant to DOE’s missions in biology and environmental sciences • Seeking programmatic outcomes broadly useful and transferable to other agencies and industry, including nuclear medicine community. • Workshop summary will lead to full report

26. Paradigm for Reconfiguration of Radiochemistry Program BER Environmental Sciences NIH Human Health Sciences BER Biological Sciences BER Foundational Research in Radiochemistry and Imaging Instrumentation

27. Biological and Environmental Research Biological Systems Science Division Triennial On-Site Review of Joint Genome Institute (JGI) (POC: Dan Drell) • December 3-5 in Walnut Creek, CA • Team of experts will evaluate science, operations, informatics and management • Criteria include scientific productivity and impact, quality of user program, and value added from JGI informatics and data analysis activities

28. Biological and Environmental Research Biological Systems Science Division Workshop on “Low Dose Epidemiology – What Can It Tell Us?” (POC: Noelle Metting) • December 10-11, Washington D.C. area • Organizing Committee includes DOE, EPA and NCI scientists • Goal is to develop an understanding of: • The value of current human low dose/low dose-rate epidemiological data • Potential to improve and expand low dose epidemiologic data • Approaches for integrating new molecular/ biological knowledge and technologies into epidemiologic studies

29. Biological and Environmental Research Biological Systems Science Division • Genomics: GTL PI Meeting (POCs: Sharlene Weatherwax and Joe Graber). • February 8-11, 2009, North Bethesda, MD • Plenary sessions will include presentations by the DOE Bioenergy Research Centers • Breakout sessions will include topics on Biohydrogen, Annotation, Multiscale Computing, ELSI and Sustainability, and Proteomics. • Includes the USDA-DOE Plant Feedstock Genomics for Bioenergy Awardee Workshop 2009

30. Biological and Environmental Research Climate and Environmental Sciences Division: Updates

31. Biological and Environmental Research Climate and Environmental Sciences Division Environmental Molecular Sciences Laboratory (EMSL) Triennial Review. (POC: Paul Bayer) • September 8-10, Richland, Washington • Expert review panel will evaluate scientific impact and operational efficiency • Criteria include: • Scientific productivity • Strategic planning • Scientific leadership

32. Biological and Environmental Research Climate and Environmental Sciences Division ARM Airborne Measurements Workshop (POC: Rick Petty) • October 14-16, Champaign, IL • Goal: To advance instrument development for and airborne measurements of atmospheric, climate-related processes • Attendees include agency reps and members of the atmospheric instrumentation community ARM Climate Research Facility (ACRF) Workshop (POC: Wanda Ferrell) • October 21-22, Reston, VA • Goal: To ensure that ACRF has the strategy and tools to meet the science needs for the next ten years. • Attendees include agency reps and scientific community

33. Biological and Environmental Research Climate and Environmental Sciences Division Workshop on Extreme Scale Computing for Climate Change Science (POC: Anjuli Bamzai-BER and Lali Chatterjee-ASCR) • November 6-7, Washington, D.C. • Dr. Warren Washington is the organizer, at the request of Dr. Orbach • Joint BER/ASCR activity to explore the potential applications of extreme-scale computing research to enable discovery in climate change science • International representatives from the climate science and high performance computing communities

34. Biological and Environmental Research BERAC Activities: Looking ahead… • JGI is working on a Strategic Plan – anticipate briefing BERAC at Feb. 2009 meeting, inviting review • Briefing by Dr. Tim Killeen, new Assistant Director of Geosciences for NSF

35. Biological and Environmental Research BERAC – Vital Contributors to BER • Strategic thinking – identifying areas of opportunity • Science leadership and forward-looking advice – beyond the horizon • Program reviews, COV’s – staying on the cutting-edge of science • Visibility – sharing our successes

36. Biological and Environmental Research Thank you!

37. Back up slides

38. BER Approach: Understanding Complex Systems • Defining multiple components and their interactions, i.e., the “whole is greater than the sum of its parts.” • Synergistic effects, emergent properties, and concomitant actions are the norm rather than the exception in all complex systems. • Systems approaches advance our understanding of molecules, organisms, ecosystems, and global climate. • Systems science will allow us to modify, regulate, and/or control biology and the environment in support of DOE missions.

39. Biological & Environmental Research (BER)(FY 2009=$568.5M) • Biological Research: • Life Sciences. Three Bioenergy Research Centers continue to accelerate research in biofuels. Genomics: GTL research is enhanced, underpinning biotech solutions for DOE energy/environmental needs. Low dose radiation research activities are enhanced. Genome sequencing at the Joint Genome Institute supports BER goals. Radiochemical and imaging research is enhanced to develop new imaging technologies and new applications for radiotracers in biology and the environment. (FY 2007=$252.5M; FY 2008=$294.7M; FY 2009=$296.2M); • Medical Applications. Supports fundamental research and instrument development in imaging for an artificial retina that allows patients to see large objects. (FY 2007=$6.6M; FY 2008=$8.2M; FY 2009=$8.2M) • Environmental Remediation Research. Providing the scientific basis for understanding DOE's legacy environmental contamination issues; EMSL initiates multi-year program for acquisition of new/improved instrumentation (FY 2007=$91.4M; FY 2008=$93.8M; FY 2009=$98.4M).

40. Biological & Environmental Research (BER) Climate Change Research: • Supports the U.S. Climate Change Science Program to develop, test and improve climate models that simulate the responses of climate to increased atmospheric greenhouse gases and aerosols. • Atmospheric Radiation Measurement (ARM) Climate Research Facility adds a second mobile system to obtain observations of clouds and aerosols in poorly understood regions. • Climate Modeling increases to exploit leadership class computing (FY 2007=$129.6M; FY 2008=$136.9M; FY 2009=$154.9M)

41. Nuclear Medicine in BER • FY 2007 Program Funding ($6.0M): Supported radiotracer and advanced imaging instrumentation for medical research and technology development activities and some imaging instrumentation work • FY 2008 Omnibus Bill: Congress provided additional $17.5M for nuclear medicine research. Formal applications to Funding Opportunity Announcement in the area of Radiochemistry and Instrumentation Research will be reviewed for scientific merit, and awards made in FY 2008.

42. U.S. Department of Energy Office of Science Biological and Environmental Research(dollars in thousands) FY 2008 FY 2009 Appropriation Request Research Life Sciences 137,775 166,206 GTL Research Centers 75,000 75,000 Climate Change Research 97,854 112,834 Environmental Remediation 46,665 48,485 Medical Applications 30,132 8,226 Total, Research 387,426 410,751 Facility Ops Scientific User Facility Operations EMSL (PNNL) 38,068 48,448 Production Genomic Facility (JGI) 60,000 55,000 ARM 35,251 37,853 Total, Facility Operations 133,319 141,301 EMSL Major Item of Equipment4,500 0 Total, Facility Ops 137,819 141,301 Other BER GPP/GPE 4,531 1,450 SBIR/STTR 14,621 15,038 Total, Other 19,152 16,488 Total, BER 544,397 568,540

43. >103 m Mesoscale 101.5-103 m Computational Modeling & Iterative Experimentation Across Scales Pore scale 10-3-101.5 m Microscopic 10-7-10-3 m Molecular/nano 10-10-10-8 m Biological and Environmental Research Subsurface Research Across Scales From the molecular to the ecosystem • Field-scale understanding based on: • Column & mesoscale research • Small-scale field experiments • Iteration between field experiments and modeling/simulation • Characteristics of groundwater flow • affecting contaminant transport at small -intermediate scales: • advection/dispersion • diffusion • stratigraphy (heterogeneity) • porosity • Reactive processes control • contaminant transport occur at • small scales: • chemical oxidation/reduction • biological oxidation/reduction • adsorption • precipitation/dissolution

44. FY 2009 President’s Request: Radiochemistry and Imaging Instrumentation Research • Reconfiguration will reflect BER's energy and environmental mission focus, areas distinct from NIH focus on developing disease diagnostics and medical therapeutics • The program will support: • Fundamental research to advance DOE’s mission in biology and environmental sciences. • New methods for real-time, high-resolution imaging of dynamic biological processes in environmentally-responsive contexts • Research will be broadly useful and transferable to other agencies and industry, including nuclear medicine research at the National Institutes of Health. Goal: Multiple use—multiple benefits from new scientific discoveries