OBESSIVE- COMPULSIVE DISORDER

2. OBESSIVE- COMPULSIVE DISORDER

3. Obsessions • repetitive and constants thoughts, images, or impulses that cause anxiety or distress • thoughts, images, or impulses not about real-life problems • Try to ignore or counter act thoughts, images, or impulses • thoughts, images, or impulses “recognized as a product of one’s own mind and not imposed from without”

4. Compulsions • Repetitive behaviors or mental acts person does in reaction to obsessions • behaviors or mental acts done to avoid or decrease distress • behaviors or mental acts are clearly excessive or not realistic

5. ICD-10(F.42) • DSM IV TR (300.3)

6. Obsessive-Compulsive Disorder • Obsessions- repetitive unwanted ideas that the person recognizes are irrational • Compulsions- repetitive, often ritualized behavior whose behavior serves to diminish anxiety caused by obsessions

7. EPIDEMIOLOGY

8. EPIDEMIOLOGY • Affects almost 3% of world’s population • In India life time prevalence of OCD is 2-3% • common in persons from upper social class and with high intelligence

9. Demographic characteristics • Gender Distribution Women appear to develop OCD slightly more frequently than men (1.5:1) Males develop OCD at a younger age than do females

10. Marital status % of patients who had never married was significantly higher rate In India OCD is more common in unmarried males. (other countries are not reported)

11. Course and nature of history • Age at onset Usually in childhood or early adult life The onset for males occurred earlier than for females (19.5±9.2 yrs Vs 22.0 ±9.8yrs)

12. Course of illness It is continuous and chronic in which patients rarely symptom free at follow up • A long term follow up studies shows that about 25% remained unimproved overtime, 50% had moderate to marked improvement while 25% had recovered completely.

13. ETIOLOGY

14. I.BIOLOGICAL THEORIES: • Neurotransmitters • Brain Serotonin(5HT) function may contribute to anxiety symptoms

16. Noradrenalin Higher plasma free 3- methoxy 4-hydroxy phenyl glycol and plasma nor-epineherine levels

17. Genetics • Family history:- OCD is found in 5-7% of first degree relatives of patients with OCD • Strongest evidence comes from twin studies

18. Electro physiological studies • EEG abnormalities can lead to OCD ( temporal lobe spikes and increased theta waves in sleep EEG)

19. Neuropsychological studies • Frontal deficit, although non dominant –parietal deficits also seen in patients with OCD

20. Brain imaging Cranial CT and MRI scans Non specific abnormalities are found in patients with OCD

21. PET scans indicate differences in brain activity of OCD patients versus normal

22. II. Behavioral theories • Learning theory suggest that obsession ritual are the equivalent of avoidance responses. • Ritual acts produce relief and thus through negative reinforcement increase the possibility of repetition of the phenomena

23. Psychodynamic theory • Freud suggested that obsessional symptoms results from repressed impulses of an aggressive or sexual nature. • Obsession symptom occur as a result of regression to the anal stage of development • It is consistent with the obsessional patient’s frequent concerns over excretory functions and dirt

24. Psycho dynamic theory Model

25. Early Child hood Disturbed development in Anal sadistic phase Normally disguised by Reaction formation Obsessional Personality traits Fixation in development Anxiety related to oedipal conflicts Regression Reinforcement of anal/aggressive impulses In presence of fixation at anal sadistic phase At present New defenses Needed as reaction formation is not enough Isolation affect undoing Displacement compulsive acts Obsessive thoughts phobias

26. Clinical features • Four clinical syndromes • Washers • Checkers • Pure obsessions • primary obsessive slowness

27. washers • Obsession is with contamination with dirt, germs, body excretions etc. • Compulsion is washing of hands or the whole body repeatedly many times a day ( clothes, bath room, door knobs, personal articles)

28. Checkers • Person has multiple doubts ( door has not been locked, kitchen gas has been left open, counting of money was not exact) • Compulsion of course is checking repeatedly to remove the doubts.

29. Pure obsessions • Repetitive intrusive thoughts, impulses or images which are not associated with compulsive acts. The content is usually sexual or aggressive in nature. • A variant is obsessive rumination, the person ruminates in his mind about pros and cons of the thoughts concerned, repetitively

30. Primary obsessive slowness • Severe obsessive ideas or extensive compulsive rituals leads to marked slowness in daily activities.

31. Assessment of OCD • Maudsley obsessional compulsive inventory (MOCI) • 30 items –true or false questionnaire • Yale Brown obsessive compulsive scale (Y-BOCS) • Rating on time spent, interference, distress, resistance and control for obsessions and compulsions

32. Diagnosis-ICD-10(F.42) • Either obsessions or compulsions (or both), present on most days for a period of at least two weeks. • The obsessional symptoms should have the following characteristics: • They must be recognized as the individuals own thoughts and impulses • There must be at least one thought or act that is still resisted un successfully, even though others may be present which he sufferer no longer resists • the thought of carrying out the act must not in itself be pleasurable • the thoughts, images or impulses must be unpleasantly repetitive.

33. Differential diagnosis • Generalized anxiety disorder • Panic disorder • Phobic disorder • Depressive disorder • Schizophrenia • Organic cerebral disorders

34. Types • F42.0 Predominantly obsessional thoughts and ruminations • F42.1 Predominantly compulsive acts • F42.2 Mixed obsessional thoughts and acts • F42.8 Other obsessive-compulsive disorders • F42.9 Obsessive-compulsive disorder, unspecified

35. Treatment

36. Pharmacological management • Benzodiazepines :-eg-alprazolam, clonazepam. • Antidepressants:- SSRI:- eg- clomipramine 75-300mg/day Fluoxetine 20-80mg/day Sertraline Fluoxamine

37. Cont…. • Antipsychotics:- Eg:- haloperidol, risperidone, olanzapine • Buspirone (anxiolytic)

38. Psychotherapy • Psychoanalytic therapy (patients) • Supportive psychotherapy (patients and family)

39. Behavioral therapy • Techniques • Thought stopping • Response prevention • Systematic desensitization • modeling

40. Electro convulsive therapy • Indications:- • Severe depression with OCD • Risk of suicide • Poor response to other mode of treatment • ECT is not the treatment of first choice in OCD

41. Psychosurgery • Perform incase of not responding to other mode of treatment • benefit is the marked reduction in associated distress and severe anxiety • Procedures • Stereotactic limbic leucotomy • Stereotactic subcaodate tractotomy

43. Reference • Mary c Townsend.psychiatric mental health nursing,3rd edition • Oxford text of psychiatry. 2nd edition • Judith Haber, Anila S . Comprehensive psychiatric nursing. 5th edition • ICD- 10 classification of mental and behavioural disorder

44. www.mayoclinic.com/.../obsessive-compulsive-disorder/DS00189 • www.webmd.com/anxiety.../obsessive-compulsive-disorder