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ISI Foundation G. Matullo, P. Vineis M. Manuguerra, F. Saletta DNA repair genes and cancer Web registry on DNA repair polymorphisms and cancer risk website www.perseus.isi.it/huge.

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  1. ISI FoundationG. Matullo, P. VineisM. Manuguerra, F. SalettaDNA repair genes and cancerWeb registry on DNA repair polymorphisms and cancer riskwebsite www.perseus.isi.it/huge

  2. The format of the database is organized by polymorphism and by study, and the contents are:- genetic characterization of the polymorphism- functional data on the physiological and pathological consequences of structural changes in genes and the related protein products (to be implemented)

  3. - design of the studies in detail :choice of controls type and stage of disease covariates methods for phenotyping/genotyping - results in detail (Odds Ratios with confidence limits; disaggregation by gender, age, exposure...)

  4. Future additional features:It will become possible to prepare meta-analyses and funnel plots from the websiteWe are preparing a matrix of phenotype-genotype correlations, based partly on he literature partly on research in our laboratory (SNP vs. COMET, HCRA, DNA adduct, 8-OH (d)G)Example: 3 SNP for XPD, XRCC1, XRCC3 in 634 healthy subjects from EPIC, and DNA adducts

  5. http://www.isi.it ISI FOUNDATION, TURIN, ITALY

  6. http://perseus.isi.it/huge ISI FOUNDATION, TURIN, ITALY

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