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The broader impact of this technology is potentially huge: Scientific

Build stable blood supply for a healthier body Yadong Wang, University of Pittsburgh, DMR 1005766.

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The broader impact of this technology is potentially huge: Scientific

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  1. Build stable blood supply for a healthier bodyYadongWang, University of Pittsburgh, DMR 1005766 We set out to design and successfully achieved robust angiogenesis using an injectable polyvalent coacervate of a polycation, heparin and FGF2. The matrix protected FGF2 from proteolytic degradation. FGF2 released from the coacervate was more effective in the differentiation of endothelial cells and chemotaxis of pericytes than free FGF2. One injection of 500 ng of FGF2 in the coacervate elicited comprehensive angiogenesis in vivo. Mature vasculature stabilized by vascular smooth muscle cells persisted till at least 4 weeks. On the other hand, bolus injection of an identical amount of free FGF2 induced weak angiogenic responses. Theseresults demonstrate the potential of polyvalent coacervate as a new controlled delivery platform. * Chu, H., Gao, J., Chen, C. W., Huard, J. & Wang, Y. Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis. Proc. Natl. Acad. Sci. U.S.A.108, 13444-13449 (2011).

  2. Build stable blood supply for a healthier body Yadong Wang, University of Pittsburgh, DMR 1005766 • The broader impact of this technology is potentially huge: • Scientific • This technology is a platform that delivers any heparin binding proteins in a highly efficient and effective manner. • There are over 30 cytokines and other proteins that bind heparin. This platform is not only a potential therapy, but also a tool for biological study. • Societal • The successful completion of this research will impact the life of millions. • The potential applications are multiple including heart diseases, wound healing, nerve regeneration, and repair bone defects.

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