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Evolution of multigene families

Evolution of multigene families. Gene duplication and multigene families. Orthologs - homologs by speciation. Paralogs - homologs by gene duplication. Phylogenetic consequences of duplication, speciation, and gene conversion in gene families.

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Evolution of multigene families

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  1. Evolution of multigene families

  2. Gene duplication and multigene families Orthologs - homologs by speciation • Paralogs - homologs by gene duplication

  3. Phylogenetic consequences of duplication, speciation, and gene conversion in gene families

  4. Identify the evolutionary events indicated by circles

  5. Gene duplication and polyploidization in plants Poplar Papaya Arabidopsis

  6. Retroposon-mediated duplication of IQD12 gene and morphological evolution in tomatoes

  7. Using age distribution of gene duplication events to infer whole-genome duplications

  8. Recent and ancient duplications in the soybean genome

  9. Origin of new gene regulatory functions

  10. Evidence for adaptive evolution in ribonuclease genes of primates

  11. Evidence for localized gene conversion & concerted evolution in primate globin gene family

  12. Immunoglobulin Vh gene family in vertebrates

  13. The vertebrate major histocompatibility complex (Mhc) Class I Class III Class II LMP TAP complement DQ DR DP DM DO DN HSP70 B C X E J A H G F Human B A A B A A B B B A B A B B B A I II III I TAP D Q T M complement K O F E M A LMP HSP70 Mouse B A B B B B A B B A II II I II I II B-G TAP B-G rDNA Chicken A B B B B B I II HSP70 complement LMP Frog I A B B B

  14. Concerted evolution of avian Mhc genes revealed by Genetree analysis A, species tree B, gene tree

  15. Phylogeny of bird and mammal Mhc class II B genes (exon3) 88 Agph-DAB1 Red-winged Blackbird Agph-DAB2 Agph1.1 96 Agph1.2 Agph1.3 Came.11 88 House Finch Came1.2 Came2.1 100 Apco1.1 Apco1.2 Apco1.3 Apco2.1 Apco3.6 birds Apco3.4 Scrub Jay Apco3.3 mammals 95 100 Apco3.2 Apco2.3 Apco2.4 Apco3.5 Apco3.1 Apco2.2 BLBI BLBII 100 100 CHKBLBETA chicken BLBIII BLBIV BLBVX HLA-DRB1 HLA-DRB7 HLA-DRB2 96 Mus-Eb mammals HLA-DOB Maru-DAB1 81 HLA-DPB Mus-Ab HLA-DQB Xenopus Xela-DAB Pore-DXB Poecilia 0.10 substitutions/site

  16. The DDC model of subfunctionalization, as illustrated by Hox genes

  17. Complementary expression patterns in duplicated zebrafish engrailed genes

  18. High rate of gene duplication(Lynch)

  19. } Using gene order to estimate times of gene duplication in yeast }

  20. Age estimates based on Ks and orthology do not match

  21. Paralogs clustering by species - a telltale sign of concerted evolution

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