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Neurological Emergency Treatment Trials Network

Neurological Emergency Treatment Trials Network. NETT Overview William Barsan, M.D. PI—NETT CCC nett.umich.edu. NETT. Funded by the NINDS in 2006 Focus on emergency care of neurological disorders Perform multiple simultaneous trials Structure Clinical Coordinating Center

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Neurological Emergency Treatment Trials Network

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  1. Neurological EmergencyTreatment Trials Network NETT OverviewWilliam Barsan, M.D.PI—NETT CCCnett.umich.edu

  2. NETT • Funded by the NINDS in 2006 • Focus on emergency care of neurological disorders • Perform multiple simultaneous trials • Structure • Clinical Coordinating Center • Statistics and Data Management Center • Hubs and spokes

  3. Neurological EmergenciesSpectrum of Pathology • Neurotrauma: Brain & Spinal Cord Injury • Stroke: Ischemic & Hemorrhagic • Status Epilepticus • CNS Infections: Meningitis & Encephalitis • Anoxic Brain Injury • Others: Bell’s Palsy, Headache, etc.

  4. Multi-disciplinary compositionNeurology, Neurosurgery, EMS, Neuro Critical Care, and Trauma • Research encompassing a continuum of care that starts in the ambulance or in the emergency department and continues in the ICU, in the OR, on the stroke unit, or in the clinic. • Network leadership, Hub PI’s, and Trial PI’s represent a range of specialties. • Breaking down specialty “silos”

  5. Mission The mission of the Neurological Emergencies Treatment Trials (NETT) Network is to improve outcomes of patients with acute neurological problems through innovative research focused on the emergent phase of patient care.

  6. Vision NETT will engage clinicians and providers at the front lines of emergency care to conduct large, simple multi-center clinical trials to answer research questions of clinical importance.   The NETT structure will be utilized to achieve economies of scale enabling cost effective, high quality research. 

  7. Clinical Trial enrollment • NETT is a Hub and Spoke network • Hubs are academic health centers (AHC) • Spokes may be AHC or community hospitals • Hubs may have variable numbers of spokes (Hub complex) • All Hub complexes participate in every trial • Not all sites within a Hub complex have to be enrolling in every trial

  8. Clinical Trials ALIAS 2 RAMPART ProTECT POINT SHINE ATACH 2

  9. NETT – Looking Forward NETT clinical trials Community outreach Adaptive clinical trials Outcomes assessment Cost benefit/effectiveness Surveillance Continued performance improvement

  10. Why Community Outreach? • Transparency • Active vs passive patient engagement • Improve credibility of results • More direct applicability to patients • Improve the value of research • Improve the public’s confidence in research

  11. LISTEN conference • Learn from patients/advocates • Education for physicians • Education for patients/advocates • What is the optimal level of involvement? • Best strategy for involvement • Identify potential participants for NETT

  12. QUESTIONS?

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