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Epidemiology in Groningen

Epidemiology in Groningen. What is epidemiology Our department Projects in our department Special Oncology. Definition of epidemiology.

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Epidemiology in Groningen

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  1. Epidemiology in Groningen • What is epidemiology • Our department • Projects in our department • Special Oncology

  2. Definition of epidemiology • “The study of the distribution and determinants of health-related states or events in specified populations, and the application of this study to control of health problems” • The study of the occurrence of a disease in a population, in relation to its determinants. http://bmj.bmjjournals.com/collections/epidem

  3. Epidemiology is occurrence research • Object of research: occurrence relation Outcome = ƒ(determinants) • Determinants are all factors that influence the frequency of a disease (causal or not-causal) • Outcome may include (other) risk factors, disorders, disease progression/cure,burden of disease, costs

  4. Department of Epidemiology at UMCGFacts • Established February 2005 • Union of epidemiology, data management and MTA groups from Medical School and Academic Hospital • Focus on own research in collaboration with strong clinical research groups • Clinical Research desk (CRD) for consultancy • Teaching in several Bachelors and Master programs, including new MSc Epidemiology program • About 65 people • 8 associate/full professors • ~25 scientific staff www.EpidemiologyGroningen.nl

  5. www.EpidemiologyGroningen.nl

  6. Scientific output 2005 • 81 PubMed publications • 27 first, second, last author • 2 PhD-theses completed (co-promotor) • 24 grant applications • ≥ 5 granted

  7. Two sections Research & Education R&E (O&O) Diabetes/obesity Cardio-renal disorders Lung diseases Oncology Psychiatry Medical statistics Genetic epidemiology MTA Research support (RCC) Management team Secretary, supporting staff Organization

  8. Department of Epidemiology Ongoing projects offering excellent research opportunities

  9. Chronic diseases are the greatest threat to quality of life and have one thing in common: ageing is the number 1 risk factor Burden through age-related diseases [worldwide loss in DALY’s1), 2005 =100%] • Diabetes Age-related (chronic) diseases • Parkinson’s • Alzheimer’s • Cancer • All diseases combined Index 2005 • Communicable, hereditaryand nutrition related diseases 1) Disability Adjusted Life Year Source: WHO, Global Burden of Disease Estimates

  10. LIFELINES • Focus on modification of universal risk factors for multifactorial diseasesPopulation-based study 165.000 participants from the northern provinces of the NetherlandsThree-generation study designMultiple UMCG departments involved www.lifelines.nl

  11. Purpose of LifeLines Central question • Why do some people get old in a healthy manner, and why have others already severe impairments or diseases early in their life? Focus on • Multifactorial diseases (gene + environment) • Factors which cause more than one disease

  12. Main focus of LifeLinesFrequently occuring diseases with high impact Note: many diseases are defined by an arbitrary cut-off in a continuous disease marker or endophenotype.

  13. LifeLines cohort dimensions The study will cover 30,000 index persons (probands or propositi) with an age between 25 and 50 years in a defined geographical area, and subsequently assess and follow their family members

  14. Mental disease- TRAILS • Aims at understanding the origins of mental disease • Provides a multitude of repeatedly measured psychosocial and biological data • Included a cohort of more than 2000 adolescents from the general population • Principally carried out by the department of Psychiatry • www.trails.nl

  15. Cardiovascular disease - PREVEND • Directed at the assessment of the impact of microalbuminuria • Focus is on renal and cardiovascular disease • Cohort study with 8592 persons from the general population • Carried out in close collaboration with the department of Internal Medicine • www.prevend.org

  16. Adiposity - GECKO • Focus on development of body weight during the first year of life • Measures of metabolism, genetics, parental life style • Includes a cohort of all children born in Drenthe during one year (N=5500) • Carried out in close collaboration with the department of Pediatrics • www.rug.nl/umcg/faculteit/disciplinegroepen/kindergeneeskunde/gecko

  17. COPD - VLAGTWEDDE/VLAARDINGEN • Sample of the general population of the Netherlands followed up for 25 years • Measurements of FEV1, single nucleotide polymorphisms, life style factors (smoking) • In collaboration with the department of Pulmonary Diseases

  18. Oncology – CANCER REGISTRY • Early detection of breast and ovarian cancer in families with BRCA mutations • Follow-up after breast cancer • Incidence and determinants of irradical tumor resection

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