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Reproductive and Perinatal Epidemiology

Reproductive and Perinatal Epidemiology. Landmark Studies. Folic acid and NTD prevention Case-control studies Intervention studies Public health interventions PROBIT study – promotion of breastfeeding trial Showed that BF has an effect on infections in 1 st yr of life, on IQ at 6.5 yrs

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Reproductive and Perinatal Epidemiology

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  1. Reproductive and Perinatal Epidemiology

  2. Landmark Studies • Folic acid and NTD prevention • Case-control studies • Intervention studies • Public health interventions • PROBIT study – promotion of breastfeeding trial • Showed that BF has an effect on infections in 1st yr of life, on IQ at 6.5 yrs • No effect on various other outcomes

  3. Why is this exciting? • Potential for huge impact on public health/society • The “value” of preventing a single birht defect or infant death • Easy to see studies through to completion • Pregnancy lasts 9 months – exposure—outcome windows are short • Methodological challenges • Lots of problems with existing methods; some simple solutions

  4. Data Sources • Prospective studies • These are relatively short, but sample sizes often need to be large • Databases • McGill Obstetric/Neonatal Database (MOND) – all births at the RVH since 1976, detailed clinical and demographic information • RVH ultrasound databases • Existing studies (e.g., PROBIT)

  5. Funding Sources • CIHR • Population/public health • Pediatrics • IHDCYH special programs • NIH • March Of Dimes • MCH and SickKids foundations

  6. Career Opportunities • Small but growing field • Several small but strong academic groups in Canada • Public Health Agency of Canada • Other Public Health groups • SPER (Paediatric and Perinatal) • Offshoot of SER that meets the day before the annual SER meeting

  7. People at McGill • Michael Kramer • PROBIT • Prematurity and socioeconomic status • Methods • Claire Infante-Rivard • Genetic epidemiology and perinatal outcomes • Robert Platt • Methods

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