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Rupinder Dhaliwal, RD Daren K. Heyland, MD Naomi E Cahill, RD Xiaoqun Sun, MSc

Evaluate the impact of feeding protocols on nutrition practices and outcomes in critically ill patients across multiple centers. Explore nutritional adequacy, clinical outcomes, and protocol variations. Results examine effectiveness and benefits of standardizing enteral nutrition delivery.

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Rupinder Dhaliwal, RD Daren K. Heyland, MD Naomi E Cahill, RD Xiaoqun Sun, MSc

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  1. Rupinder Dhaliwal, RD Daren K. Heyland, MD Naomi E Cahill, RD Xiaoqun Sun, MSc Andrew G Day, MSc Stephen A. McClave, MD The Impact of Enteral Feeding Protocols on Enteral Nutrition Delivery:Results of a multicenter observational study 1

  2. Background 1 • Feeding protocols are considered to be an effective strategy to maximize the benefits and minimize the risks of enteral nutrition in critically ill patients. • Components of feeding protocols may include orders for • Early initiation of enteral nutrition • Use of motility agents • Gastric residual volumes • Head of the bed elevation • Use of small bowel feeding tubes • The benefits of such protocols would be: • to standardize the delivery of EN • to automate the provision of EN

  3. What do Guidelines say? “Use of a feeding protocol that incorporates prokinetics at initiation, higher GRVs (250 mls) and use of post pyloric feeding tubes should be considered” “Evaluating gastric residual volume (GRV) in critically ill patients is an optional part of a monitoring plan to assess tolerance of EN. “ Avoid holding EN when GRV < 250 mls. Consensus, imperative “Use of enteral feeding protocols increases the overall percentage of goal calories provided and should be implemented.” Avoid holding EN for GRVs < 500 mls. Grade: C, B 1

  4. RCT Level of Evidence RCTs of aggressive feeding protocols Results in better protein-energy intake Associated with reduced complications and improved survival • Taylor et al Crit Care Med 1999; Martin CMAJ 2004; Doig GS JAMA 2008 • However, the estimates of their effectiveness are limited due to: • the nature of small single-center studies • the bundling with many other interventions in cluster • randomized controlled trials. 1

  5. Purpose • To evaluate the effect of an ICU site-based feeding protocol on nutrition practices and outcomes in the context of an international multicenter, observational study. • Objective • To compare the following performance criteria between sites that did or did not use a feeding protocol: • Use of EN • Time to start EN • Adequacy of enteral nutrition • Adequacy of overall nutrition • Clinical outcomes 1

  6. Primary Outcomes 1 Overall nutritional adequacy Enteral nutrition adequacy Overall nutritional adequacy = as the total amount of calories or protein received (from EN + appropriate PN + propofol) /prescribed x 100% Overall EN adequacy = as the total amount of calories or protein received (from EN) /prescribed x 100%

  7. Methods Data from two international, prospectively, observational cohort studies conducted in 2007 and 2008 were combined. Patients: Consecutively enrolled mechanically ventilated adults In ICU > 3 days Data was collected from ICU admission to a maximum of 12 days: sites recorded the presence or absence of a feeding protocol timing, type and amount of nutrition received strategies utilized to improve nutrition delivery (m. agents, small bowel feeds, HOB) 60 day mortality, hospital and ICU length of stay and duration of mechanical ventilation Each participating ICU aimed to recruit 20 patients. Nutrition practices and clinical outcomes were compared between ICUs that used a feeding protocol and those who did not. 1

  8. Data Management Data entered on to our secure online edcs, built-in range checks and data query process. 1 www.criticalcarenutrition.com

  9. Data Analysis Data from 2007 and 2008 combined, 334 total sites, 65 sites participated both years, 269 unique ICUs Hospital and ICU characteristics compared at the site level All other variables were compared at the patient level Clustered 2 stage sample design: patient and site, so potential for heterogeneity between ICUs. Advanced statistical methods were done to account for heterogeneity (adjusted chi square tests, multilevel modelling). 1

  10. Results 269 ICUs participated from 28 countries 2007: 128/167 (77%) used protocol 2008: 132/167 (79%) used protocol

  11. Results 269 ICUs participated from 28 countries Ireland 7/7 (100%) Canada 46/57 (80.7%) China 16/25 (64%) UK 19/19 (100%) USA 48/77 (62.3%) Italy 7/7 (100%) India 5/9 (55.5%) New Zealand 6/7 (85.7%) Brazil 2/4 (50%) Australia 28/28 (100%) 29/61 (48%) of the non-protocolized sites being from the United States.

  12. Results: Site Characteristics

  13. Results: Feeding Protocols • 15.2% using the recommended threshold volume of 250 ml 1

  14. Results: Patients n = 5497 Heyland JPEN 2010 ( in press) 1

  15. Results: Nutrition outcomes Heyland JPEN 2010 ( in press) 1

  16. Results: Nutrition Adequacy Heyland JPEN 2010 ( in press) 1

  17. Heyland JPEN 2010 ( in press) EN adequacy: multilevel model After adjusting for the effect of: significant patient characteristics (age, BMI, gender, # days in ICU, surgical vs. Medical, APACHE II) site level characteristics of EN adequacy (year of survey, vs. Non teaching, closed, RD, glycemic protocols) The expected average EN adequacy over the first 12 ICU days 1

  18. Conclusions There is great variation in the use of feeding protocols in ICUs across the World. The presence of an enteral feeding protocol is associated with significant improvements in the use of EN, timing of initiation of EN, the use of motility agents and nutrition adequacy delivered. We suggest that the use of feeding protocols become standard of care in ICUs. Despite the use of protocols, overall nutrition adequacy is still below target, further refinement and optimization of the characteristics of feeding protocols is warranted. The positive effect of feeding protocols on clinical outcomes is yet to be established. Heyland JPEN 2010 ( in press) 1

  19. Strengths and Weaknesses Weaknesses • observational nature of the study design • did not standardize the specific nutrition interventions included in the feeding protocols • did not optimize the utilization of protocols at each site. We are unable to comment on the quality of these existing protocols or the level of compliance at the bed-side. Strengths • large number of participating sites from around the world • Use of a structured, validated data capture system, which enhances the generalizability and validity of the observations. 1 Heyland JPEN 2010 ( in press)

  20. Efficacy of Enhanced Protein-Energy Provision via the Enteral Route in Critically Ill Patients: The PEP uP Protocol A Single center feasibility trial Daren K. Heyland Professor of Medicine Queen’s University, Kingston General Hospital Kingston, ON Canada SP14

  21. The authors are grateful to the critical care practitioners from all participating ICU sites for their dedication and commitment to collecting data for this study. Colleagues at the Clinical Evaluation Research Unit Naomi Cahill currently holds a Canadian Institutes for Health Research (CIHR) Fellowship in Knowledge Translation. All authors declare no conflicts of interest relevant to the subject of this manuscript. Acknowledgements 1

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