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One Step Synthesis of Biotinylated ‘Smart’ Polymers Heather D. Maynard, University of California, Los Angeles CHE-041635

One Step Synthesis of Biotinylated ‘Smart’ Polymers Heather D. Maynard, University of California, Los Angeles CHE-0416359.

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One Step Synthesis of Biotinylated ‘Smart’ Polymers Heather D. Maynard, University of California, Los Angeles CHE-041635

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  1. One Step Synthesis of Biotinylated ‘Smart’ Polymers Heather D. Maynard, University of California, Los Angeles CHE-0416359 ‘Smart’ polymers respond to environmental cues such as temperature. Conjugates of synthetic ‘smart’ polymers with proteins have important applications in nanotechnology and biotechnology as sensors and switches. We have prepared a well-defined poly(NIPAAm) that has biotin or vitamin H at one end (upper left) in one step. This polymer is not soluble in water at higher temperatures and is soluble at lower temperatures (left). Because the polymer has a biotin at one end, it readily binds to the important protein streptavidin (below). Biotin or vitamin H Poly(NIPAAm) DT ‘Smart’ polymer solubility in water depends on temperature + biotinylated poly(NIPAAm) streptavidin Streptavidin-‘smart’ polymer conjugate Bontempo, D.; Li, R.C.; Ly, T.; Brubaker, C.E.; Maynard, H.D. Chem. Commun. 2005, 4702-4704.

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