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http: doctorsforlifeinternational

Doctors For Life International: An NGO’s perspective on Malaria in Southern Africa Bola Omoniyi, Ph.D. http: www.doctorsforlifeinternational.com. Who we are NGO, NPO Founded in 1991 Over 1300 Medical professionals 75% Africa based HQ: South Africa Operations in SADC countries. What we do

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http: doctorsforlifeinternational

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  1. Doctors For Life International: An NGO’s perspective on Malaria in Southern AfricaBola Omoniyi, Ph.D. http: www.doctorsforlifeinternational.com

  2. Who we are NGO, NPO Founded in 1991 Over 1300 Medical professionals 75% Africa based HQ: South Africa Operations in SADC countries What we do Malaria R & D (Artemisia) Access to Medicines Care of Orphans & Vulnerable Children Home Based (AIDS) Care Life Skills Education WorkPlace AIDS Programs Care of Abused Women Doctors For Life (DFL) International

  3. Caring for Orphans and Vulnerable Children

  4. Reaching People With No Access to Medical Care

  5. Taking Medical Care to AIDS Patients at Home

  6. Education Life Skills Based HIV/AIDS Prevention

  7. Developing Artemisia for Treatment of Malaria in Poor and Rural Communities

  8. Malaria – Southern Africa • South Africa: Decreasing incidence of malaria • Mozambique: Primary cause of ill health. • 40% of outpatients, 60% of pediatric patients • One third of all hospital deaths • More than 90% of children infected in most areas • Significant contributor to high infant & under- 5 mortality • 15-30% deaths in pregnant women. • Poor rural communities with little medical access most affected. • Angola: Number one killer

  9. Malaria Map – Southern Africa Department of Health RSA

  10. Plasmodium Falciparum • Majority of cases in South Africa • Most South Africans are non-immune • Low altitude areas of NE S. Africa • P. vivax and P.ovale are rare • Seasonal Transmission: Oct - May

  11. Quinine Artemisinin derivatives Mefloquine Tetracyclines Clindamycin Chloroquine Halofantrine Available Anti-Malarials

  12. Choice of Treatment • Severity of malaria • Resistance pattern • Parasite species • Patient characteristic – age, pregnancy • Geography; Kwazulu-Natal, Limpopo, Mpumalanga

  13. Products under Development • Doctors For Life International (DFL): Artemisia • South African Traditional Medicines Group (SATMERG): Screening of Plant extracts. 25/500 plants with anti-malarial activity identified. • National Bioproducts Institute (BPI): Rapid malaria diagnostic kit ( designed for use in rural areas) Ongoing Research: • South African Malaria Initiative (SAMI): drug discovery, diagnostics and epidemiology • National Institute of Communicable Diseases (NICD): Insecticide resistance • University of Cape Town (UCT): Mechanism of chloroquine resistance reversal

  14. Artemisia based product Capsules Under preclinical and clinical development Pilot study in the DRC Doctors For Life: Malarlife

  15. Mozambique: Improving Malaria Prevention in Rural Areas

  16. Mozambique: Decreasing Malaria Related Mortality in Children

  17. Mozambique: Health Education and Access to Medicines

  18. Angola – Reaching People in War Ravaged Areas

  19. Angola – Tackling Malaria in RuralAreas

  20. Doctors For Life: Future Goals • Development of effective and affordable artemisia-based treatment for Malaria • Combining artemisia with other effective and affordable products to tackle recrudescence • Establish a permanent presence in Mozambique and Angola • Expand care of orphans and vulnerable children • Expand HIV prevention programs • Increase effective collaboration with other organizations and international agencies working on Malaria & HIV/AIDS

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