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Cooperative Human Tissue Network (CHTN): NCI Biospecimen Resource

CHTN, established in 1987, offers high-quality tissue specimens for cancer research. Procurement includes various sample types like blood, plasma, and more. Scientific impact includes numerous publications and patents supporting research.

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Cooperative Human Tissue Network (CHTN): NCI Biospecimen Resource

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  1. The Cooperative Human Tissue Network (CHTN): An NCI-Supported Biospecimen Resource open to the Scientific Community https://www.chtn.org/ Rodrigo Chuaqui, MD Pathology Investigation and Resources Branch, Cancer Diagnosis Program, Division of Cancer Treatment and Diagnosis

  2. Cooperative Human Tissue Network (CHTN) Established 1987 by NCI in response to an increase in demand to high quality of specimen for cancer research (Vand. U) (OSU) (U. Penn) (UVA) (Nationwide Children’s H.) (UAB)

  3. Tissue Samples and Extracts Procured by the CHTN 2005-2010 Fresh Frozen Paraffin Embedded/Blocks Tissue Microarrays RNA/DNA Nitrocellulose and Other Blots Other Malignant Preinvasive Neoplasia Uninvolved/Normal Benign Non-neoplastic Diseased Other • Blood • Buccal Mucosa • Buffy Coat • Lavage • Peripheral Effusion • Peripheral Blood • Plasma Body Fluids Procured by the CHTN 2005-2010 * • Serum • Sinus Contents • Sputum • Stool • Urine * Not all Divisions

  4. CHTN: Scientific Impact • 3,900 publications using CHTN samples • 268 patents issued since 1987 • Supports Basic/Discovery Phase Research (RO1, R21, R33) • Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection (Doitsh et al, Nature 2014) • Polyomavirus integration and Merkel tumor (Feng et al, Science 2008) • Single cell sequencing and tumor evolution (Navin et al, Nature 2011) • B-cell derived lymphotoxin promotes castration-resistant prostate cancer (Ammirante et al, Nature 2010) • Paracrine requirement for hedgehog signaling in cancer (Yauch et al, Nature 2008) • Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations (Pugh et al, Nature 2012) https://www.chtn.org/

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