1 / 17

NEONATAL JAUNDICE

Definition . JAUNDICE: yellowish discoloration of skin, sclera and mucus membraneResults from accumulation of un conjugated bilirubin pigment in the skin occur in 60% of term infant and 80% of preterm infant.. Bilirubin production . Bilirubin is a product of heme catabolism. Approximately 80 to 90%

danno
Download Presentation

NEONATAL JAUNDICE

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    1. NEONATAL JAUNDICE (??????? ???????) ?.???? ???? ????

    2. Definition JAUNDICE: yellowish discoloration of skin, sclera and mucus membrane Results from accumulation of un conjugated bilirubin pigment in the skin occur in 60% of term infant and 80% of preterm infant.

    3. Bilirubin production Bilirubin is a product of heme catabolism. Approximately 80 to 90% of bilirubin is produced during the breakdown of hemoglobin from red blood cells (RBCs). Hemoglobin globin +heme co +biliverdine Bilirubin +albumin hepatocyte (glucuronic acid) bilirubin diglucuronides + bilirubin monoglucuronides.+ Conjugated bilirubin Conjugated bilirubin is secreted into the bile, and then excreted into the digestive tract. conjugated bilirubin is reduced to urobilin. Un conjugated bilirubin : lipid soluble can cross blood brain barrier and its neurotoxic. Conjugated bilirubin: water soluble not neurotoxic it indicates serious liver disorder .

More Related