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The Complexity of Bacterial Vaginosis:

The Complexity of Bacterial Vaginosis:. Do Gardnerella vaginalis biofilms contribute to the growth of other anaerobes associated with bacterial vaginosis?. Annica Stull-Lane BBSI 2008. VCU Mentor: Kimberly Jefferson. Home Mentor: Taylor Allen. What is Bacterial Vaginosis (BV)?.

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The Complexity of Bacterial Vaginosis:

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  1. The Complexity of Bacterial Vaginosis: Do Gardnerella vaginalis biofilms contribute to the growth of other anaerobes associated with bacterial vaginosis? Annica Stull-Lane BBSI 2008 VCU Mentor: Kimberly Jefferson Home Mentor: Taylor Allen

  2. What is Bacterial Vaginosis (BV)? • Most common vaginal disorder in reproductive women, world-wide • Characterized by: 1) raised pH, 2) overgrowth of unhealthy anaerobes, 3) reduction of lactobacilli http://www.yamagiku.co.jp/pathology/photo/photo138-1.htm

  3. Preterm delivery Increased risk of pelvic inflammatory disease (PID) Increased susceptibility to HIV acquisition/transmission Recurring! Treatment Complications with BV http://the-half-decent-pharmaceutical-chemistry-blog.chemblogs.org/archives/2006/11/23/drug-of-the-week-metronidazole

  4. Etiology and Pathogenesis of BV? • Not fully known • Sexually transmitted? • Important connection between characterization factors Reduction of lactobacilli Reduction in H2O2 production Overgrowth of BV associated bacteria Raised pH Wilson, J. Managing recurrent bacterial vaginosis. Sex Transm Infect 2004;80:8-11.

  5. Swidsinski A, Mendling W, Loening-Baucke V, et al. Adherent biofilms in bacterial vaginosis. Obstet Gynecol 2005;106.5;1012-23. BV-associated bacteria • Gardnerella vaginalis—most prevalent • Other anaerobes, including: • Atopobium vaginae • Prevotella bivia • Mobiluncus vaginalis • Biofilm Gardnerella vaginalis biofilm

  6. Hypothesis • Gardnerella vaginalis is the initial colonizer • This allows for other BV-associated anaerobes to adhere to the vaginal epithelium and survive in the presence of O2, lactic acid, H2O2 etc…

  7. Experiment • Mathematical Modeling • How effectively would a G. vaginalis biofilm deplete O2 • Wet lab work • Test tolerance of anaerobes grown alone or with G. vaginalis biofilm to O2 and other chemicals • Analyze adherence of anaerobes to vaginal epithelial cells and to G. vaginalis biofilms Anaerobes: Atopobium vaginae, Prevotella bivia, Mobiluncus vaginalis

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