Electroconducting hydrogels synthesized by pyrrole- hyaluronic acid conjugates

1. Electroconducting hydrogels synthesized by pyrrole-hyaluronic acid conjugates Jae Young Lee, Stephanie K. Seidlits, Christine E. Schmidt

2. Schematics • Chemical modification of hyaluronic acid with pyrrole • Crosslinking pyrrole-HA conjugates by oxidation, mediated by pyrrole moieties • Further incorporation of polypyrrole chains with additional exogenous pyroles

3. Preparation of PPy-HA hydrogels • Various Compositions with respect to oxidant (APS) and spiked pyrrole APS* = ammonium persulfate

4. Crosslinked hydrogels • Optical images PyHA w/ Py(0)APS(M) HA w/ Py(0)APS(M)

5. Optical images of crosslinked PPy-HA hydrogels Py(0)APS(M) Py(L)APS(M) Py(M)APS(M)

6. Swelling properties of the hydrogels • Incubated in PBS for 24 hours.

7. Rheological properties of the hydrogels

8. ATR-IR spectra of the hydrogels

9. Morphologies of the hydrogels • The samples were freeze-dried and coated with 10 nm thick Pt/Pd for SEM imaging. Py(M)APS(M)

10. Conducting properties characterized using EIS - 1

11. Conducting properties characterized using EIS - 2