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VSEL

A. bGH- WT (6M). bGH- TG (6 M). bGH- WT (1Y). bGH- TG (1 Y). MNC. MNC. MNC. MNC. MNC. MNC. MNC. MNC. MNC. MNC. HSC. VSEL. HSC. HSC. HSC. HSC. VSEL. VSEL. VSEL. VSEL. VSEL. HSC. VSEL. VSEL. VSEL. VSEL. HSC. HSC. HSC. HSC. BstUI. BstUI. H19. H19. -. -. -. -.

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VSEL

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  1. A bGH-WT (6M) bGH-TG (6 M) bGH-WT (1Y) bGH-TG (1 Y) MNC MNC MNC MNC MNC MNC MNC MNC MNC MNC HSC VSEL HSC HSC HSC HSC VSEL VSEL VSEL VSEL VSEL HSC VSEL VSEL VSEL VSEL HSC HSC HSC HSC BstUI BstUI H19 H19 - - - - - - + + + + + + - - - - - - + + + + + + - - - - - - + + + + + + - - - - - - + + + + + + - - - - - - + + + + + + - - - - - - + + + + + + Rasgrf1 Rasgrf1 * * B Prop1df/+ (20 M) Prop1df/df (20 M) GHR+/- (20 M) GHR-/- (20 M) MNC MNC HSC VSEL VSEL HSC BstUI BstUI H19 H19 Igf2-H19-DMR Igf2-H19-DMR C Prop1df/df(2 M) + GH Prop1df/df(2 M) + Saline Prop1df/df (8 M) + GH Prop1df/df (8 M) + Saline BstUI BstUI H19 H19 Supplementary Figure 1

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