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Bioinformatics Platform Three-tier Architecture

Static Pages (SHTML) for Web Site. Dynamic pages (JSPs) for database driven Entry, Dissemination and Queries. Middleware implemented using Entity-Class Operations, Servlets in Java. Part of CFG database overall ontology map. Object-based Relational Database implemented using Oracle.

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Bioinformatics Platform Three-tier Architecture

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  1. Static Pages (SHTML) for Web Site Dynamic pages (JSPs) for database driven Entry, Dissemination and Queries Middleware implemented using Entity-Class Operations, Servlets in Java Part of CFG database overall ontology map Object-based Relational Database implemented using Oracle Bioinformatics PlatformThree-tier Architecture • Top-most layer of user interface • Static pages for web site management • Dynamic pages for database driven content • Communicates with database and user • Keeps the complexity of the database • Invisible from user interface • Enables seamless acquisition and • dissemination of data • Entity Relationship data model • Ontology Diagram • Implementation using Oracle

  2. Data IntegrationOverall Schema for CFG Data Objects

  3. Data IntegrationApproach to Functional Glycomics Glycan profile of spleen of FucT-VII KO mice with differences in histology staining

  4. Data IntegrationApproach to Functional Glycomics Expression of glycan related genes in wildtype mouse spleen

  5. Automated Acquisition Data from Public databases, links to Public resources Data from Cores Interface to CFG resources and data Expert Contribution Filling out fields as experts on the molecule Molecule Page Interface Comprises of three main components Molecule Information Portal

  6. GBP Molecule Page Galectin family chosen

  7. Galectin-3 Molecule Page Molecule Page of Galectin-3: General Tab Galectin-3 selected

  8. Galectin-3 Molecule Page Reference Tab: Links to Public Databases

  9. Galectin-3 Molecule Page Genome Tab Link to CFG Transgenic mice

  10. Galectin-3 Molecule Page Domain Organization Proteome Tab

  11. Select High Signal Spot Galectin-3 Molecule Page Link to glycan structure corresponding to high affinity ligand of GBP Link to CFG Glycan Array Data Glycome Tab Link from high affinity glycan to GBP molecule page

  12. Galectin-3 Molecule Page Histological Staining Data Biology Tab Immunology Data Metabolism Data Links to CFG Phenotyping data on Galectin-3 KO mice

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