Clinical and Translational Science Awards (CTSAs): Building Connections February 4, 2009

1. National Center forResearch Resources A c c e l e r a t i n g a n d e n h a n c i n g r e s e a r c h f r o m b a s i c d i s c o v e r y t o i m p r o v e d p a t I e n t c a r e NATIONAL INSTITUTES OF HEALTH Clinical and Translational Science Awards (CTSAs): Building Connections February 4, 2009 National Advisory Council on Drug Abuse Barbara Alving, MD, MACP Director National Center for Research Resources

2. National Center for Research Resources Accelerating research from basic discovery to improved patient care Animalmodel resources community engagement Improved patient care Pre-clinical Community imaging & informatics advances Clinicalresearch support Clinical

3. Implement biomedical discoveries Develop, test, and bring new prevention strategies into medical practice more rapidly Catalyze change - lower barriers between disciplines Encourage creative and innovative approaches Impetus for the CTSA Program To ensure new discoveries lead to improved public health, clinical science must evolve to better: CTSAWeb.org

4. WA ME MT ND VT OR MN NH WI ID NY MA SD WY RI MI NJ PA IA NE NV OH MD IN DE IL UT CO WV KS VA CA MO KY NC TN OK AZ AR SC NM GA AL MS LA TX AK FL HI PR CTSAs – Building a National Consortiumof Academic Health Centers Currently 38 CTSAs Sites Across the Country CT Participating Institutions Members 2006 & 2007 New Members 2008

5. Kaiser Permanente Georgia CDC Yerkes National Primate Research Center Emory University Georgia Tech Morehouse School of Medicine Children’s Healthcare of Atlanta Complex Carbohydrate Research Center at U Georgia Atlanta VAMedical Center Georgia Research Alliance Georgia Bio CTSA – Providing Local Leveraging Opportunities Atlanta Clinical and Translational Science Institute (Atlanta-CTSI) at Emory University

6. CTSA – Creating National Partnership Opportunities Consortium Governance Advisory: providing guidance and input to the NCRR Director Oversight: identifying and selecting collaborative opportunities to facilitate research, coordinating Consortium-wide approaches to research, and overseeing topic-specific efforts across the Consortium Steering: coordinating institutional topic-specific efforts with the national CTSA Consortium; each Steering Committee has an Operations subgroup that takes timely action on emergent topic issues www.ctsaweb.org

7. Goal One: Enhancing National Clinical and Translational Research Capability Clinical research management Research infrastructure Phenotyping – human and preclinical models Goal Two: Enhancing Training and Career Development of Clinical and Translational Investigators Goal Three: Enhancing Consortium-Wide Collaborations Social networking Inventory of resources Data sharing Goal Four: Enhancing the Health of Our Communities and the Nation Community engagement Public health policy CTSA National Strategic Plan Priorities

8. CTSA – Creating National Partnership Opportunities Working as a Consortium, we have established a committee structure to execute the vision and goals of the CTSA program

9. CTSAweb.org Resources for Researchers Building Connections e-Newsletter Communication Toolkit

10. CTSA – Creating Regional Partnership Opportunities = CTSA Institutions = East Coast Consortium = Midwest Consortium = West Coast Consortium Mayo Clinic College of Medicine Universityof Iowa University of Washington University of Chicago University of Wisconsin Oregon Health & Science University University of Rochester Yale University University of California, Davis Weill Cornell Medical College Columbia University University of California, San Francisco Rockefeller University Albert Einstein College of Medicine Stanford University The Scripps Research Institute Washington University in St. Louis

11. Implementation and development of tools for clinical investigators to facilitate small and medium sized research studies Enhance the collection and management of data in small and medium sized studies Requirements At least three CTSA must collaborate Data and software sharing Must incorporate institutional database support that is flexible, secure, and easily accessible on demand Encouraging and Enhancing Collaboration CTSA Consortium – Informatics Pilots Clinical and Translational Information Exchange Environment Informatics Pilots

12. PhysioMIMI at Case Western Reserve University Includes investigators from Marshfield Clinic, University of Wisconsin and University of Michigan Collects, manages, and analyzes diverse data types across institutions Allows secure, safe and regulated transfer of information from clinical care systems and research databases Sharing Clinical Data at University of Washington Includes investigators from University of California, San Francisco, University of California, Davis Allow researchers to access large shared datasets Assist with designing research studies and generating hypotheses Research Electronic Data Capture (REDCap) at Vanderbilt Includes investigators from Oregon Health and Sciences University and Mayo Clinic Provide an easy way for researchers to develop a secure, web-based application for collecting, managing and sharing of their clinical and translational research data Create secure and flexible interoperability between REDCap and external data systems thus ensuring data quality in information exchange Informatics Pilot Projects

13. Informatics Pilots University of Washington WA ME MT ND MansfieldClinic University of Wisconsin– Madison Oregon Health & Science University VT OR MN NH WI ID NY MA SD University of Michigan CT Mayo Clinic College of Medicine WY RI MI NJ PA IA University of California, Davis NE NV OH MD IN DE IL UT Case Western Reserve University CO WV University of California, San Francisco KS VA CA MO KY Vanderbilt University NC TN OK AZ AR SC NM GA AL MS LA TX AK FL HI PR

14. Develop business plans, design, and implement community surveys Create innovative cross-educational programs Develop case studies to pilot programs Collaborate with international colleagues Prepare cost analyses Protect CTSA-developed patents Form industry partnership programs CTSA Consortium – Building Connections with Business Schools CTSA are partnering with business schools to:

15. Emergency Medicine Sleep Research Network Critical Care Neurology Neuroimaging Encouraging and Enhancing Collaboration NIH Opportunities CTSA Thematic Research Networks/CTSA Interest Groups

16. Doubled the clinical and translational training workforce from 2006 - 2008 Increased the number of regional training interactions among consortium sites Awarded a supplement to develop a National CTSA Educational Resource Program (NCERP) that will: Identify, catalog, and assess training modules in clinical and translational research Enhance and broaden training opportunities for clinician-scientists across the CTSA consortium Educational Impact of CTSA Program

17. # of Investigators # of Trainees and Scholars Field of Training 272 29 50 10 9 16 7 20 10 18 5 5 8 10 7 _____37 513 Clinical Disciplines (includes 37 subcategories) Pediatric Disciplines Public Health Stats, Res Methods, Informatics Genetics Allied Health Immunology Nursing Bioengineering Neuroscience Psychology, non-clinical Physiology Microbiology and Infect Diseases Pharmacology Molecular Biology Other Total 3,948 516 317 176 134 121 115 110 108 108 93 77 69 61 53 ____250 6,256 Educational Impact of CTSA Program(Based on 2008 Annual Progress Reports from first 24 CTSAs)

18. CTSA Consortium and NIDA Collaborations(Based on 2008 Annual Progress Reports from first 24 CTSAs) NIDA Grants Utilizing CTSAs

19. CTSA Consortium and NIDA Collaborations(Based on 2008 Annual Progress Reports from first 24 CTSAs) NIDA Grants Utilizing CTSAs

20. Established in 1999 to conduct research in a wide variety of community based treatment programs across the United States. Provides a unique opportunity to address a variety of underserved populations, and in particular to evaluate access to and effectiveness of treatments for ethnic minorities. Seeks to reduce barriers to all its studies and has attended carefully to recruitment and retention of women and ethnic minority groups. NIDA Clinical Trials Network Clinical Trials Network (CTN)

21. WA ME MT ND VT MN OR NH NY WI ID MA SD CT WY RI MI NJ PA IA NE NV OH MD IN DE IL UT CTN Node CO WV KS VA CA MO KY NC TN States with CTSAs NM OK AZ SC AR GA AL MS TX LA AK FL HI PR Opportunities for Partnership with CTSAs and NIDA Clinical Trials Network

22. Funding Opportunities at NIDA

23. National Center for Research Resourceswww.ncrr.nih.gov Translating Research from Basic Discovery to Improved Patient Care