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Tricarboxylic Acid Cycle

Tricarboxylic Acid Cycle. -: Prepared by :- Mr. Ansari Altamash Shakeel Ahmad Assistant Professor Department of Pharmaceutical Chemistry Y. B. Chavan College of Pharmacy, Aurangabad, MS. India. email:- altamash263@gmail.com Mobile:- 09823967266

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Tricarboxylic Acid Cycle

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  1. Tricarboxylic Acid Cycle -: Prepared by :- Mr. Ansari Altamash Shakeel Ahmad Assistant Professor Department of Pharmaceutical Chemistry Y. B. Chavan College of Pharmacy, Aurangabad, MS. India. email:- altamash263@gmail.com Mobile:- 09823967266 You tube: www.youtube/krebs cycle by Altamash Ansari Facebook: kerb's cycle by Altamash Ansari

  2. CITRIC ACID CYCLE Tricarboxylic acid cycle (TCA) Or Krebs cycle

  3. INTRODUCTION • Described by Hans Adolf Krebs in 1937 • A feature of cell chemistry shared by all types of life. • A complex series of reactions beginning and ending with the compound oxaloacetate. • The cycle produces carbon dioxide and the energy-rich compound ATP.

  4. INTRODUCTION • Eight successive reaction steps. • The six carbon citrate is formed from two carbon acetyl-CoA and four carbon oxaloacetate. • Oxidation of citrate yields CO2 and regenerates oxaloacetate. • The energy released is captured in the reduced coenzymes NADH and FADH2.

  5. LOCATION The citric acid cycle enzymes are found in the matrix of the mitochondria

  6. OVERVIEW OF KREBS CYCLE Acetyl CoA (2C) CoA CO2 CO2

  7. Conversion of Pyruvate to Acetyl CoA PDH Pyruvate + NDH+ CoA Acetyl CoA + CO2 + NADH + H+ 3ATP

  8. Formation of Citric Acid

  9. Dehydration/Hydration

  10. Decarboxylation

  11. Oxidative Decarboxylation

  12. Oxidation

  13. Hydration

  14. Dehydrogenation

  15. Pyruvate (3C) Acetyl CoA (2C) Pyruvate dehydrogenase CoA SH CO2 NAD NADH+H CoA SH Citrate synthase Citrate (6C) H2O Aconitase Oxaloacetate (4C) Cis -Aconitate H2O Aconitase Malate dehydrogenase NAD NADH+H Isocitrate Malate (4C) Isocitrate dehydrogenase NADH+H NAD H2O oxalosuccinate Fumarase CO2 Isocitrate dehydrogenase Fumarate (4C) α-ketoglutarate Succinyl CoA Succinatedehydrogenase α-ketoglutarate dehydrogenase NADH+H NAD CO2 FAD FADH2 CoA SH Succinate (4C) GTP GDP Succinatethiokinase

  16. Summary of the Krebs Cycle One turn of the Krebs Cycle Generates: 2 Carbon dioxide molecules 3 NADH molecules 1 FADH2 molecule 1 ATP molecule TOTAL 4 carbon dioxide molecules 6 NADH molecules 2 FADH2 molecules 2 ATP molecules

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