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An Inventory of Certified Reference Materials as Quality Assurance Tools related to AMPS

This inventory provides information on the availability and status of Certified Reference Materials (CRMs) related to Analytical Methods and Procedures (AMPS). It includes a list of CRMs for calibration and validation purposes, as well as the lack of CRMs for specific matrices and compounds. The inventory aims to identify areas where additional input from CRM producers is needed and to discuss the development of new Matrix-CRMs to support AMPS. The results of this overview will be published in a scientific journal.

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An Inventory of Certified Reference Materials as Quality Assurance Tools related to AMPS

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  1. An Inventory of Certified Reference Materials as Quality Assurance Tools related to AMPS B. M. Gawlik, O. Bercaru, F. Ulberth RM/BG/31-Jan-2003

  2. Information sources • BCR-Catalogue; • Catalogues of European Reference Material Producers (CD-ROM); • Catalogues of other providers; • COMAR-Database (www.comar.bam.de); • Literature research. RM/BG/31-Jan-2003

  3. Status overview - generalities • CRMs for calibration (pure substances and solutions) vs. CRMs for validation (matrix-related); • Substantial number of CRMs for inorganic PS for both purposes. • Considerable number of materials related to sediments and aquatic biota. • No materials at all for particulate matter as a matrix. • Real Matrix-CRMs for water are hardly feasible. Alternative solutions are under development. RM/BG/31-Jan-2003

  4. Status Overview - particularities • A considerable lack of aquatic CRMs , especially Matrix-CRMs for atrazine, benzene, chlrofenvinphos, 1,2-dichloroethane, diuron, endosulfan, isoproturon, simazine and chloroform. • No Matrix-CRM at all for dichloromethane, fluoranthene, trichlorobenzene (available in soil), trifluraline. NB: sufficiently pure standards are not a problem. • No CRMs at all for alachlor, brominated diphenylethers, C10-13 chloroalkanes, DEHP, nonyl- and octylphenol. RM/BG/31-Jan-2003

  5. Status Overview - particularities • Availability of Calibration-CRMs for organo-metallic compounds as well as labelled compounds for isotope dilution techniques are problematic, too. • To be discussed: representativity of matrices and target concentrations. --> input from CEN 230 needed. • Issue of Horizontal harmonisation (possibility, does it make sense, for what); • PAH reference materials for water under production at IRMM. RM/BG/31-Jan-2003

  6. Conclusions • In particular the issues of standards for alachlor, brominated diphenylethers, C10-13 chloroalkanes, DEHP, nonyl- and octylphenol, organo-metallic compounds require additional input from CRM Producers (even without AMPS); • Concerning new Matrix-CRMs in support to AMPS, definitions of working ranges and representative matrices will be necessary (at later stage?!). • Results of this overview to be published in Anal. Bioanal. Chem. (Fresenius’ J. Anal Chem). RM/BG/31-Jan-2003

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