MOTOR AREAS EXTRAPYRAMIDAL SYSTEM

1. MOTOR AREAS EXTRAPYRAMIDAL SYSTEM

2. Definition: Tracts other than corticospinal tract are Knownas extrapyramidal tracts. The word extrapyramidal is slowly being replacedby Corticonuclear & corticobulbar tracts.

3. Components of extrapyramidal system • Basal Ganglia • Midbraingiving rise to following bulbospinaltracts: • Rubrospinaltract. • Vestibulospinal Tract. • Reticulospinal Tract • Tectspinal Tract. • Olivospinal Tract.

4. Descending Spinal Pathwaysextrapyramidal system - Coordination of head & eye movements, - Coordinated function of trunk & extremity musculature to maintaining posture and balance - Synapse in some intermediate nucleus rather than directly with lower motor neurons

6. Reticulospinal Tract The reticular formation makes up a central core through much of the brainstem. It contains many different nuclear groups. Pontine and medullary nuclei projects to the anterior horn of the spinal cord. Functions:influence motor functions as for example voluntary& reflex movement and is also responsible for the muscle tone.

7. Olivospinal Tract It arises in the cells of inferior olive of the medulla and is found only in the cervical region of the spinal cord. Function is unknown.

8. Role of the brain stem Support of the Body Against Gravity. Roles of the Reticular and Vestibular nuclei.

10. 1- The vestibular nuclei: Selectively control the excitatory signals to the different antigravity muscles (the muscles of vertebral column and the extensor muscles of the limbs). to maintain equilibrium in response to signals from the vestibular apparatus. 2- The medullary reticular system: Transmit inhibitory signals to the same antigravity anterior motor neurons (medullary reticulospinal tract). So that under normal conditions, the body muscles are normally tense.

11. Functions of the Cerebellum Anterior and posterior lobes govern subconscious aspects of skeletal muscle movements. Flocculondular lobe on inferior surface contributes to equilibrium and balance. Main functions: Cerebellum evaluates movements • smoothes movements • corrects errors • coordinates sequence • regulates posture and balance • makes possible all skilled muscular activities

12. Table 13.2 part 3

14. BASAL GANGLIA AND CONTROL OF MOTOR FUNCTIONS

15. BASAL GANGLIA THE BASAL GANGLIA ARE MASSES OF GREY MATTER MADE OF CELL BODIES LYING DEEP INSIDE THE WHITE MATTER OF THE CEREBRUM, AND MAKES UP PART OFTHE MIDBRAIN. An upper mass is called the caudate nucleus, is separated from a lower mass, the lentiform nucleus. The lentiform nucleus consists of the putamen and the globuspallidus. Other nuclei include the substantia nigraand subthalamic nucleus.

16. Basal Nuclei Caudate Nucleus Corpus Striatum Lenticular Nucleus Putamen Globus Pallidus Subthalamic Nucleus SubstantiaNigra

18. Connections for Motor Control

19. Functions of Basal Ganglia • Control of movements • Planning and programming of movements • Cognition

20. The Putamen Circuit Executes Learned Patterns of Motor Activity Basal ganglia function in association with the corticospinal system to control complex patterns of motor activity. Examples are: • writing of letters of the alphabet. • cutting paper with scissors, • hammering nails, • shooting a basketball through a hoop, • passing a football, • throwing a baseball, • the movements of shoveling, • most aspects of vocalization, • controlled movements of the eyes • virtually any other of our skilled movements, most of them performed subconsciously.

21. The Caudate Circuit Cognitive Control of Sequences of Motor Patterns: Cognition means the thinking processes of the brain, using both sensory input to the brain plus information already stored in memory. Thoughts are generated in the mind by a process called cognitive control of motor activity. Example: A person seeing a lion approach and then responding instantaneously and automatically by: (1) turning away from the lion, (2) beginning to run, and (3) even attempting to climb a tree. Thus, cognitive control of motor activity determines subconsciously, and within seconds, which patterns of movement will be used together to achieve a complex goal.

22. The Caudate Circuit Change the Timing and to Scale the Intensity of Movements. Two important capabilities of the brain in controlling movement are: (1) to determine how rapidly the movement is to be performed and (2) to control how large the movement will be. For instance, a person may write the letter "a" slowly or rapidly. Also, he or she may write a small "a" on a piece of paper or a large "a" on a chalkboard. Regardless of the choice, the proportional characteristics of the letter remain nearly the same.

23. Movement Disorders • Hypokinetic • Parkinson’s Disease • Drug Induced (Neuroleptics, MPTP) • Hyperkinetic • Hemiballismus • Huntington’s Disease • Athetosis

24. Parkinson’s Disease PD Loss of dopamine-generating cells normal

25. Parkinson’s Disease SubstantiaNigra, Loss of DOPAminergic Neurons Clinical Feature (1) Slowness of Movement - Difficulty in Initiation and Cessation of Movement

26. Parkinson’s Disease Clinical Feature (2) Resting Tremor Parkinsonian Posture Rigidity-Cogwheel Rigidity

27. Parkinson’s Disease • Described by James Parkinson • Degeneration of dopamine-generating cells in the substantianigra(60-80 %). • Five cardinal features • Tremor • Rigidity • Akinesia & Bradykinesia • Postural Changes • Speech Changes

28. Huntington’s Disease • Hereditory , autosomal dominant • Rare onset at 30-40s as early as 20s • Disease of caudate & putamen. • Early, Jerky movement of hands toward end of reaching an object • Later, hyperkinetic choreiform movements appear and gradually increase until they incapacitate the patient • Slurred speech and incomprehensive • Progressive Dementia