DF/HCC Tumor Imaging Metrics Core

1. DF/HCC Tumor Imaging Metrics Core Description Scientific Accomplishments Mission The mission of the Tumor Imaging Metrics Core (TIMC) is to provide reliable and consistent standardized tumor measurements to evaluate treatment response for DF/HCC clinical trials. As an independent core lab the TIMC provides objective anatomic and functional imaging measurements which enhances the efficiency and quality of clinical trials using this service. Reliable tracking of lesion size and/or function is essential in clinical trials that use radiological measurements as surrogate endpoints. Key Accomplishments The DF/HCC established the TIMC as a Core-in-Development on July 1, 2004 with startup funding. Since then the TIMC has hired staff, developed software and database infrastructure, completed pilot testing and designed operation manuals and SOPs. In October 2005, TIMC began formal operations, providing quantitative tumor measurements for clinical trials. In February 2007, TIMC was elevated to full Core status. Core Co-Leaders Gordon J. Harris, Ph.D., Associate Professor of Radiology, Harvard Medical School, Director 3D Imaging Service, Director, Radiology Computer Aided Diagnostics Laboratory (RAD CADx LAB), Massachusetts General Hospital Matthew A. Barish, M.D.,Assistant Professor of Radiology, Harvard Medical School, Director, 3D & Image Processing Center (3DIPC), Brigham and Women’s Hospital Annick D. Van den Abbeele, M.D., Associate Professor of Radiology, Harvard Medical School, Acting Chief Department of Radiology, Dana-Farber Cancer Institute • Usage Growth • Currently providing service to 42 Phase I, II, III clinical trials with 860 completed scans till date • Service to Lymphoma, Melanoma, Sarcoma, GIST, Colon, Lung, Pancreatic, Brain, Ovarian and Breast Cancer Disease Groups • Web-based reporting • Web-based graphical user interface provides standardized tumor measurements, graphical longitudinal, summary statistics, and snapshot views of tumor measurements • Services Offered • Protocol Consultation • Consultative services for imaging components of clinical trial protocols for DF/HCC Investigators • Assistance with optimizing the design of image analysis methods • Image Study Management • Transfer of radiology exams from DF/HCC institutions’ PACS (and outside imaging sites via CD) for processing and archival • Support for MRI, CT, PET and multi-modality fused scans • Tumor Measurements • Standardized linear, volumetric, and SUV measurements • Database Management • HIPAA and IRB compliant with Audit trail • Web-based Order-Entry System • Results Reporting • Secure online longitudinal results presented as a multimedia report with graphs & images • Data available for import into other systems TIMC Usage Growth to date Protocol Response Chart per patient • Core Personnel • Core Manager: William B. Hanlon, M.S. • Database Developer: Vadim Frenkel, M.S. • Lead Image Analyst: Trinity A. Urban, B.A. • Research Fellow: Vaibhav Sahai, M.D., M.S. • Administrator: Deirdre Pierce, B.A. Secure web-access to annotated images, graphs and tables • Core Accolades • Development of a Centralized Service for Standardized Tumor Measurements at a Multi-Institutional Collaborative Cancer Center. Education Exhibit RSNA 2006 Certificate of Merit • TIMC invited to present at National Cancer Institute (NCI) Imaging Response Assessment Teams (IRAT) Network February 2007 Locations Massachusetts General Hospital 3D Imaging Service 25 New Chardon Street Brigham and Women’s Hospital 3D and Image Processing Center 75 Francis Street Dana-Farber Cancer Institute Department of Radiology 44 Binney Street Patient Response Graph per lesion • Future Plans • Develop interfaces to Hospital Information Systems (HIS) and Electronic Data Capture (EDC) systems to improve workflow • Electronic signature in compliance with 21CFR Part 11 Regulations Websites http://tumormetrics.org http://www.dfhcc.harvard.edu TIMC Core Co-Leaders TIMC presentation at RSNA 2006