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Mutations. Gene Mutation. Gene mutation is the change in the order of the A,G,C,T bases in a gene These altered genes can have a positive, negative or no effect on the organism. Types of Mutations. Deletion- One base is missing The Gene should be AC T GCGT But instead is ACGCGT
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Gene Mutation • Gene mutation is the change in the order of the A,G,C,T bases in a gene • These altered genes can have a positive, negative or no effect on the organism
Types of Mutations • Deletion- One base is missing The Gene should be ACTGCGT But instead is ACGCGT • Addition- One extra base is added The Gene should be ACTGCGT But instead is ACTGTCGT • Substitution-One base is substituted for another The Gene should be ACTGCGT But instead is ACGGCGT
How do the X-Men’s superpowers relate to mutation? The addition, deletion, or substitution let to different proteins being made Ex) Wolverine’s mutation of his DNA produced proteins that could rapidly repair broken cells X-Men
X-Men Mutations= Not Likely • What do real mutations result in? • Check out some real mutations
Would the following mutations be harmful, beneficial, or have no impact?
Would the following mutations be harmful, beneficial, or have no impact? This is the usual appearance of the pepper moth. It blends right in with its surroundings to avoid being eaten.
However, factories in an area polluted and the trees became a blackish color
Would the following mutations be harmful, beneficial, or have no impact? As a result of a mutation, a black version of the pepper moth is now better suited
Would the following mutations be harmful, beneficial, or have no impact?
Positive Mutation • The mutation of a gene has a positive impact on the organism • Ex) Mutated gene that creates a protein that prevents HIV from infecting the organism
Negative Mutation • Small changes in certain genes have harmful affects on the organism Ex) Sickle cell anemia
Neutral Mutation • The mutation has no impact on the organism • Ex) Spirit Bear
Mutagens • Substances or factors that cause mutation in DNA • Ex) UV Light, x-rays, pollutants and other harmful chemicals
Correcting Mutations • Gene Therapy- replace a mutated gene with a healthy copy • Complicated and highly experimental