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Bootstrap method in estimation of variance of model parameters. Aims. A means to calculate confidence intervals and standard deviations for single data. The original curve fitting. TAC fitted curve model parameter estimates bootstrap residuals weighted residuals A=.
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Bootstrap method in estimation of variance of model parameters
Aims • A means to calculate confidence intervals and standard deviations for single data
The original curve fitting • TAC • fitted curve • model parameter estimates • bootstrap residuals • weighted residuals • A=
R new TAC’s and R new estimates • ordered sampling from A with replacement • by adding residuals to original TAC we get new imaginary TAC • curve fitting new estimates
Confidence intervals for estimates • R estimates of original estimate are arranged in ascending order thus • -percentile where
Kaisa Sederholm: Globaali optimointi positroniemissiotomografia-kuvantamiseen liittyvässä mallintamisessa, 2003