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Question 1

Question 1. For use in drug development what are some important principles for developing algorithms that classify mutational constellations as “drug resistant”? How should mutational algorithms and/or phenotypic breakpoints be developed in the future?. Question 2.

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Question 1

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  1. Question 1 • For use in drug development what are some important principles for developing algorithms that classify mutational constellations as “drug resistant”? How should mutational algorithms and/or phenotypic breakpoints be developed in the future?

  2. Question 2 • In addition to the covariates and methodology for assessing treatment response included in the DAP what additional covariates or methodologies should be considered when evaluating resistance data?

  3. Question 3 • Do the data presented support the clinical utility of HIV genotypic testing for use in drug development?

  4. Question 4 • Do the data presented support the clinical utility of HIV phenotypic testing for use in drug development?

  5. Question 5 • What are the limitations of the data correlating mutational patterns with clinical outcome?

  6. Question 6 • What additional clinical studies are needed to further define the clinical utility of resistance testing?

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