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Predicting Serious Drug Side Effects in Gastroenterology - PRED4 International IBD Genetics Consortium Projects www.ibdresearch.co.uk/pred4. Welcome to the OCTOBER 2013 edition of the PRED4 newsletter.
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Predicting Serious Drug Side Effects in Gastroenterology - PRED4 International IBD Genetics Consortium Projects www.ibdresearch.co.uk/pred4 Welcome to the OCTOBER 2013 edition of the PRED4 newsletter Many thanks for recruiting to the PRED4 study, we are recruiting well but need an extra drive to recruit patients into the TNF and PPI arms of the study. The most successful way to increase recruitment is to involve your neurology, rheumatology and dermatology (TNF) and renal (PPI) consultants. Please see a reminder below of some of the tips to assist you with recruiting to the Anti-TNF and PPI arms. Thank you all very much for your efforts to date. The PRED4 study incorporates: TIP – Thiopurine induced Pancreatitis; TIM – Thiopurine induced myelosupression; PPI – PPI induced nephrotoxicity ; TNF – Anti- TNF induced demyelination Please can we ask you to send in your CRF forms as soon as possible. You may also use the eCRF for entering clinical data www.ibdresearch.net. Please contact the team to obtain a user name . Thank you. Tips which we have found helpful to identify patients Talk to your Neurologists, Rheumatologists and Dermatologists (and Neurophysiology) Contact imaging for MRI scans and cross check with codes for UC (K51) and CD (K50); Arthropathies (M00-M25) and Spondyloarthropathies (M45-M49); G35-G37 (Demyelinating diseases of the CNS); or other conditions for which the Anti-TNFα is being used. Codes for identifying patients with PPI induced renal failure: M13.1 (Percutaneous needle biopsy of lesion of kidney) + N10 and N12 (Acute tubulo-interstitial nephritis) OR Y53 (Side effects from Gastrointestinal drugs) If you have clinic letters available in an electronic format, ask your IT department do a search for patients seen by the Renal team with PPI / omeprazole etc in the “Diagnosis” or “Medical history” sections. We have found that raising the profile of the Anti-TNF/ PPI study to our neurology and renal colleagues has also been very successful. E.g. MDT meetings or at lunch time presentations. We can also provide you with laminated inclusion criteria to place in clinic rooms. IBD Research Team and how to contact us: Marian Parkinson - Tel: 01392 403812 marian.parkinson@nhs.net And Clare Heard - Tel: 01392 403818 clare.heard@nhs.net Junior doctors: Drs Abhey Singh (TNF) abhey.singh@nhs.net ; Graham Heap (TIP/TIM) grahamheap@nhs.net Noami Edney naomi.edney@nhs.net (PPI) Dr Tariq Ahmad (Chief Investigator) E-mail: tariq.ahmad1@nhs.net Claire Bewshea – IBD Research Project Manager E-mail: claire.bewshea@nhs.net Tel: 01392 406928 Mobile: 07828146468