KDIGO Overview

1. KDIGO Overview

2. Mission Governance Clinical Practice Guidelines Controversies Conferences Guideline Coordination Guideline Implementation Website KDIGO

3. KDIGO Mission

4. KDIGO An independently incorporated nonprofit foundation, governed by an international board, with the stated mission to:‘Improve the care and outcomes of kidney disease patients worldwide through promoting coordination, collaboration, and integration of initiatives to develop and implement clinical practice guidelines.’

5. KDIGO Governance

6. Organizational Structure Nominating committee Board of Councelors(retired BOD members) Board Management: National Kidney Foundation Executive Committee Evidence review: Evidence Review Team Tufts NEMC • KDIGO Workgroups • CPG Workgroups • Liaison Task Force • Implementation Task Force Foundation under Belgium law

7. Omar I. Abboud, MD, SUDAN Sharon Adler, MD, USA Rajiv Agarwal, USA Sharon P. Andreoli, MD, USA Robert Atkins, MD, AUSTRALIA Gavin Becker, MD, AUSTRALIA Fred Brown, MBA, USA Daniel Cattran, MD, CANADA Allan Collins, MD, USA Josef Coresh, MD, USA Ricardo Correa-Rotter, MD, MEXICO Adrian Covic, MD, ROMANIA Jonathon Craig, MD, AUSTRALIA Angel de Francisco, MD, SPAIN Paul de Jong, MD, NETHERLANDS Tilman Drüeke, MD, FRANCE Ana Figueiredo, RN, BRAZIL Mohammed Benghanem Gharbi, MD, MORROCO Gordon Guyatt, MD, CANADA Philip Halloran, MD, CANADA David Harris, MD, AUSTRALIA Enyu Imai, MD, JAPAN KDIGO Board of Directors Co-Chairs:Kai-Uwe Eckardt, MDGERMANY Bertram Kasiske, MDUSA

8. Michel Jadoul, MD, BELGIUM Simon Jenkins, Patient, UK Vivekanand Jha, MD, INDIA Suhnggwon Kim, MD, KOREA Martin Kuhlmann, MD, GERMANY Nathan Levin, MD, USA Phillip K.T. Li, MD, HONG KONG Zhi-Hong Liu, MD, CHINA Pablo Massari, MD, ARGENTINA Peter McCullough, MD, USA Rafique Moosa, MD, SOUTH AFRICA Miguel C. Riella, MD, BRAZIL Bernardo Rodriguez-Iturbe, MD, VENEZUELA Robert Schrier, MD USA Hooi Lai Seong, MD, MALAYSIA Justin Silver, MD, ISRAEL Lesley Stevens, MD, USA Marcello Tonelli, CANADA Yusuke Tsukamoto, MD, JAPAN Theodor Vogels, MSW, NETHERLANDS David Wheeler, MD, UK Elena Zakharova, MD, RUSSIA KDIGO Board of Directors

9. Executive Committee Co-chairs: Kai-Uwe Eckardt Germany Bertram Kasiske United States Past co-chairs:Norbert Lameire Belgium Garabed Eknoyan United States Members: Josef Coresh United States Jonathon Craig Australia Angel de Francisco Spain Michel Jadoul Belgium Nathan Levin United States Miguel Riella Brazil Robert Schrier United States Yusuke Tsukamoto Japan David Wheeler United Kingdom

10. Clinical Practice Guidelines

11. Guiding Principles for KDIGO Guideline Development • Scientific and methodological rigor • Interdisciplinary approach • Independence of work groups • Transparency of the guideline development process

12. Grading: The Quality of the Evidence and the Strength of the Recommendation • 2 components of final grade:  granularity and transparency • Although quality of evidence influences strength of recommendation, no direct link • “Neutral“ alphanumeric code instead of terms that may be interpreted differently e.g. (Grade 1C) or (Grade 2D) ……(8 options) Plus option to include statements that are not graded

13. Published Clinical Practice Guidelines • Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in CKD • Published in Kidney International in April, 2008 • Diagnosis, Evaluation, Prevention, and Treatment of CKD-MBD • Published in Kidney International in July, 2009 • Care of Kidney Transplant Recipients • Published in the American Journal of Transplantation in October, 2009; Executive Summary published inKidney International in December, 2009

14. Guidelines in Development • Acute Kidney Injury • Chairs: John Kellum & Norbert Lameire • Anticipated Publication: June, 2011 • Glomerulonephritis • Chairs: John Feehally & Dan Cattran • Anticipated Publication: August, 2011 • Blood Pressure in CKD • Chairs: Gavin Becker & David Wheeler • Anticipated Publication: October, 2011

15. Guidelines in Development • Anemia in CKD • Chairs: John McMurray and Patrick Parfrey • Anticipated Publication: November, 2011 • CKD Classification and Treatment • Chairs: Adeera Levin and Paul Stevens • Anticipated Publication: July, 2012 • Lipids in CKD • Chairs: Marcello Tonelli and Christoph Wanner • Anticipated Publication: August, 2013 • Peritoneal Dialysis • Chairs: Philip Li and • Anticipated Publication: 2013

16. Controversies Conferences

17. 2010 KDIGO Controversies Conferences • Drug Prescribing in Kidney Disease: Initiative for Improved Dosing (May 2010) Co-chairs: George Aronoff and Patrick Murray • Cardiovascular Disease in CKD: What is it and what can we do about it? (October 2010) Co-chairs: Eberhard Ritz and Charles Herzog

18. 2011 Planned KDIGO Controversies Conferences • Novel Dialysis Techniques (October 2011) Co-Chairs: Christopher Chan, Nathan Levin and Francesco Locatelli • Diabetes in CKD (March 2012) Co-Chairs: Mark Molitch and Carl Mogensen

19. Guideline Coordination

20. Collaborating Guideline Groups • Canadian Society of Nephrology (CSN) Guidelines • Caring for Australians with Renal Impairment (CARI) Guidelines - ANZSN • United Kingdom Renal Association Guidelines • European Renal Best Practice (ERBP) – ERA/EDTA • Kidney Disease Outcomes Quality Initiative (KDOQI) Guidelines – NKF • ISN Guideline Committee

21. Guideline Coordination • Liaison Task Force • Global Guideline Coordination Group • ISN/KDIGO Collaboration Group

22. Guideline Implementation

23. Guideline Implementation • Publish Guidelines in multiple languages on KDIGO website and in regional journals • Commentaries from ISN, KDOQI, ERBP, UK-RA, CARI, and CSN • Develop professional education tools based on KDIGO Guidelines • KDIGO Implementation Task Force

24. Implementation Task Force The KDIGO Implementation Task Force is charged with promoting awareness, dissemination, adoption and clinical integration of KDIGO Clinical Practice Guidelines locally, around the world.

25. Implementation Task Force Task Force divided into 6 regions Each Task Force Leader has designated Regional Representatives from the countries within their region There will be different approaches to guideline dissemination depending on the region and on the country Type the Presentation Title here – Type the Presentation Subtitle here

26. KDIGO Implementation Task Force LEADERREGION Yusuke Tsukamoto (Chair) Asia Pacific Michelle Josephson North America Miguel Riella Latin America Michel Jadoul Western Europe Andrzej Więcek Eastern Europe Mona Al Rukhaimi Middle East/Africa

27. Implementation Task Force Activities: Facilitate and increase the number of presentations on KDIGO guidelines at local, national, and regional meetings. Translate and submit guideline translations and executive summaries to regional journals for publication.

28. Activities: Promote integration and adoption of guidelines into residency training programs. Assist in developing commentaries / editorials on KDIGO Guidelines for publication in regional journals. Communicate with regional healthcare administrators to promote adoption of practice guidelines. Implementation Task Force

29. KDIGO Website www.kdigo.org

30. Website Resources • KDIGO Guidelines: • All published guidelines available • Recommendations translated into multiple languages • Slide presentations • Reports from Controversies Conferences • Published position statements • Conference presentations

31. Website Resources • Global Nephrology Guideline Database: • Guideline Overviews by Organization • Guideline Summaries by Clinical Topic

32. Thank you