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This study by Martin et al. demonstrates the effectiveness of a multivalent adenovirus-based immunotherapy in inducing diverse, strong, and multifunctional T-cells in both naive and HBV-tolerant mice. The treatment shows promise for chronic hepatitis B management.
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Martin et al, ABSTRACT 130 A MULTIVALENT ADENOVIRUS-BASED IMMUNOTHERAPEUTIC FOR TREATMENT OF CHRONIC HEPATITIS B INDUCES BROAD, ROBUST AND POLYFUNCTIONAL T CELLS IN NAIVE AND HBV TOLERANT MICE