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Wie Halbleitertechnologie die Medizintechnik revolutioniert

Wie Halbleitertechnologie die Medizintechnik revolutioniert. Design & Elektronik Developers' Forum: "Embedded Goes Medical" Leipzig, September 2009. Matthias Feulner Marketing Manager m-feulner2@ti.com. Semiconductors Impact . Communications revolution. Healthcare revolution.

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Wie Halbleitertechnologie die Medizintechnik revolutioniert

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  1. Wie Halbleitertechnologie die Medizintechnik revolutioniert Design & Elektronik Developers' Forum: "Embedded Goes Medical" Leipzig, September 2009 Matthias Feulner Marketing Manager m-feulner2@ti.com

  2. Semiconductors Impact Communications revolution Healthcare revolution Computingrevolution Healthcare transformed Computing transformed Communications transformed 1980s 1990s 2000 and beyond

  3. Making devices smaller… 2008 Bluetooth®+FM Single Chip GSM/GPRSSingle Chip LoCosto™ Wireless LAN 2000 Single-chip GPS EDGE single-chip eCosto™ 1990

  4. …, more personal… Weight Management 2.4GHz ISM (Zigbee/BT/802.15.4/ULP) Bluetooth / BLE Chronic Disease Management GSM/GPRS Zigbee / 802.15.4 Vital Signs Monitoring 800 MHz / 900 MHz ISM Bluetooth / BLE Blood pressure monitor Smart bandage Weight scale

  5. … sensing and diagnosing Smart Bandage For in-hospital and out-of-hospital continuous wireless monitoring of vital signs and other physiological data directly off the body • Body worn monitoring devices Chip + Sensor + printed battery in a low cost DISPOSABLE package • Real time • Intelligent • Continuous • Wireless ECG / Heart rate Temperature Activity / Motion Respiration Location EVOLUTION REVOLUTION Wireless portable patient monitor Patient monitor

  6. Uncomfortable Doctor’s office Laboratory Radiology center + + Comfortable Patient’s home Innovation In the field Innovation Across all Medical Segments Diagnostic, patient monitoring and therapy Consumer medical devices Medical imaging Medical instruments • Digital thermometers • Blood glucose monitor • Blood pressure monitor • Insulin pumps • Heart rate monitors • Audiology (digital hearing aids) • ECG • EEG • Blood oxygen (pulse oximeter) • Blood pressure • Temperature • Ventilation/ respiration • Defibrillators • Implantable devices • Ultrasound • CT • MRI • X-Ray • Other imaging (nuclear, positron emission tomography) • Laboratory equipment • Dialysis machines • Analytical instruments • Surgical instruments • Dental instruments

  7. Addressing the Major Challenges More Cost-Efficient More Portable Smaller & Lighter More Power-Efficient More Connected

  8. Addressing the Major Challenges- Consumer Medical Case More Cost-Efficient More Portable Smaller & Lighter More Power-Efficient More Connected

  9. Consumer Medical Devices -Achieving Highest Level of Integration and Cost Efficiency ADC DAC LCD Display LCD Driver MSP430FG439 MCU Op Amp Bio Sensor Signal Processing Op Amp VRef

  10. Heart rate monitor based on SoC -Achieving Highest Level of Integration • Single chip SoC integration results in: • over 50% size reduction (from 8+ chips to a single MSP430FG439 micro controller) • ~50% cost reduction on semiconductors, circuit board and mechanical housing • 10x increased battery life time, allowing lifetime sealed medical units with small coin cell batteries.

  11. Addressing the Major Challenges- Portable Diagnostics & Therapy Case More Cost-Efficient More Portable Smaller & Lighter More Power-Efficient More Connected

  12. Portability for ECG Systems Portable ECG images courtesy of Corscience

  13. Integrated 8-Channel ECG System Solution Traditional 8-Channel ECG System Solution 24bit 24bit 24bit Filter Filter Filter S S S r r r ADC ADC ADC 24bit 24bit 24bit Filter Filter Filter S S S r r r ADC ADC ADC 24bit 24bit 24bit Filter Filter Filter S S S r r r ADC ADC ADC 24bit 24bit 24bit Filter Filter Filter S S S r r r ADC ADC ADC Mux Mux Control Interface Control Interface 24bit 24bit 24bit Filter Filter Filter S S S r r r ADC ADC ADC Switching / Switching / 24 - bit S r ADC 24bit 24bit 24bit Filter Filter Filter S S S r r r ADC ADC ADC 24bit 24bit 24bit Filter Filter Filter S S S r r r ADC ADC ADC 24bit 24bit 24bit Filter Filter Filter S S S r r r ADC ADC ADC R(RA) Protect Amp Amp IA IA L(LA) Amp Amp BT BT Protect IA IA F(LL) Amp Amp Protect IA IA Amp Amp • Integration results in: • ~50% size reduction • ~20% cost reduction • ~20% power reduction C1(V1) Protect Amp Amp IA IA RTC RTC C2(V2) Lead Selection Lead Selection Protect Amp Amp IA IA m C SD SD MSP430 C3(V3) Protect Amp Amp IA IA CF CF C4(V4) Protect Amp Amp IA IA USB USB RS23 C5(V5) 2 Protect Amp Amp IA IA BUTTON I/F BUTTON I/F PSU PSU Monitor Monitor Disp Disp C6(V6) Protect Amp Amp Charge Charge Lamp Lamp r r Lead Off + + Calibration PACE DETECT Temp 3x Comparator Ref RLD Protect Amp Amp

  14. Integrated ECG Solution Demonstrated Integrated 16ch ADC ADS1258

  15. Addressing the Major Challenges- Portable Ultrasound Case More Cost-Efficient More Portable Smaller & Lighter More Power-Efficient More Connected

  16. Bringing Ultrasound to the Point-of-Care Military Mt. Everest Tsunami Images courtesy of Sonosite

  17. Integration Steps for Portable Ultrasound Embedded Processing Analog signal chain Tx Buffer Amp FET Driver Front End HV MUX Passive Transmit Beamformer Beamformer Control Unit DAC LPF Receive Beamformer T/R Switches Transducer Mid Analog Front End Amp Stage Amp + Filter Preprocessing Clocking Low Pass Filter PGA LNA VCA ADC Back End B Mode Processing Color/Power Doppler Processing SpectralDoppler Processing ADC CW (analog)Beamformer Scan Conversion Post Processing Ultrasound OS/UI AudioAmp Common Interfaces LPW RS232 USB 1394 802.11 Backlight Power Touchscreen Memory Interfaces MMC/SDIO IDE/ATA

  18. Integration Steps for Portable Ultrasound High-PerformanceDSP DSP SoC/Apps. processor High-PerformanceDSP High-PerformanceDSP Embedded processing Analog signal chain Tx Buffer Amp FET Driver Front End Front end HV MUX Passive Transmit Beamformer Beamformer Control Unit DAC LPF Receive Beamformer T/R Switches Transducer Mid Mid Analog Front End Amp Stage Amp + Filter Preprocessing Clocking Low Pass Filter PGA LNA VCA ADC Back End B Mode Processing Color/Power Doppler Processing Back end SpectralDoppler Processing ADC CW (analog)Beamformer Scan Conversion Post Processing Ultrasound OS/UI AudioAmp Common interfaces LPW RS232 USB 1394 802.11 Backlight Power Touchscreen Memory interfaces MMC/SDIO IDE/ATA

  19. Ultrasound Receiver Front-End Integration Path 15mm 9mm AFE5805EVM

  20. Portable Ultrasound Demonstrator Implemented32 channels Tx & Rx on Analog Front End Board DAC902 TX734 AFE5805 CDCE62005 DM6446 Phantom Image Mimicking Tissue Mimicking Vessel Analog Front End Board Reflectors Digital Processing Board

  21. What are the Major Challenges?- Wireless Medical Sensors Case (BAN / AAL) More Cost-Efficient More Portable Smaller & Lighter More Power-Efficient More Connected

  22. Goal: Reduce Wires for Patient Comfort Now go to sleep … 14-year old David during a sleep test • Three electrodes on head • Two electrodes on forehead • One electrode next to each eye • Two electrodes under mouth • Two electrodes on each leg • A pulse oximeter on the finger • A chest belt for respiration monitor • A breathing tube • …all collected on the blue box • From the blue box, a very thick cable ran to the computer that collected all the signals

  23. Solution: Wireless Connected Vital Sensors Hardware: Universal platform for the transfer of biosignals Telematik Thermometers Sphygmomanometers Smart Sensors The interconnection of new sensors with Peak-Flowmeter new sensor concepts By microsystems technology Software: Interface standards Scales Transfer of data via SMS Pulsoximeter continous Monitoring 3 channelsECG Courtesy of FZI Karlsruhe

  24. Application in Experimental Monitoring Jacket Continous measurement of Blood pressure change Activity sensor ECG Wireless communication (BlueTooth) Electronics Courtesy of FZI Karlsruhe

  25. Wireless Connectivity for Medical applications Potential Wireless Standards } • Passive RFID • Active RFID • 802.15.4/ Zigbee • Bluetooth Low Energy • Bluetooth • IEEE 802.11b • IEEE 802.11a/g • IEEE 802.11n • UWB • Sub-1GHz ISM

  26. Wireless Connectivity for Medical applications What is LE Bluetooth? • Simplified version of Bluetooth optimized for low power • Low average power – quick initialization of links • Low peak current – suitable for coin cell usage CC2540 LE – Low Energy CC2540 Dual mode device (GTLE+Bluetooth BR/EDR) Single mode device (BTLE only) CC2540

  27. Wireless Connectivity for Medical applications BT Classic vs. BT LE BT Classic (BR/EDR) Bluetooth Low Energy (BLE ) ISM bandwidth 2.400-2.4835 GHz 2.400-2.4835 GHz Star + Piconet Pure Star (no piconet) Topology Master send page, Slave scan Master scans, slave advertises Device Discovery 1, 2 or 3 Mbps 1 Mbps Data rate Range 5-10 m 5-10 m Modulation GFSK (BR), PSK (EDR) GFSK (index 0.5) Data (ACL) Voice (SCO), Data (ACL) Packet Formats Spec: -70 dbmBL6450: -95 dbm (BR) Spec: -70 dbmBL6450: slightly better than -92 dbm Sensitivity (BER=0.1%) AES-CCM (NIST approved) Pseudo random XOR sequence Security HCI Shared BR/EDR/ULP HCI (in dual-mode) Init connection: 35mA for 10mS, ~10mA for <100mS Peak Current Consumption (peak) Init connection: 17mA for 128uS CC2540 Average Power Consumption (Dual Mode) Data transfer once a minute: 70uA Paired – not connected 320uA Data transfer once a minute: 53uA Paired – not connected: 190uA Data transfer once a minute: 7uA Paired – not connected: 4uA Data transfer once a minute: 70uA Paired – not connected: 320uA Average Power Consumption(Single Mode) CC2540

  28. Wireless Connectivity for Medical applications BLE Enabled by CC2540 System-on-a-chip (SoC) Chronic Disease Management Vital Signs Monitoring Blood pressure monitor Smart bandage Weight scale Weight Management CC2540 BLE evaluation kit with USB dongle CC2540 BLE coin cell demo

  29. Health Care Revolution

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