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11/15/2014

400 years of Passion & Performance. Since 1614. 11/15/2014. | 1. Dutch Universities: Research with Focus on Top Sectors. Cooperation with Russia in Field of Life-Science & Health Sibrandes Poppema. Scientific output 2002-2012. 1. USA 3,250,380 51,546,027 15.86

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11/15/2014

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  1. 400 years of Passion & Performance Since 1614 11/15/2014 | 1 Dutch Universities: Research with Focus on Top Sectors. Cooperation with Russia in Field of Life-Science & HealthSibrandes Poppema

  2. Scientific output 2002-2012 1. USA 3,250,380 51,546,027 15.86 2. PEOPLES REP CHINA 1,022,597 6,653,426 6.51 3. GERMANY 845,448 11,340,845 13.41 4. JAPAN 803,857 8,390,864 10.44 5. ENGLAND 747,867 11,306,492 15.12 6. FRANCE 603,328 7,556,253 12.52 7. CANADA 493,736 6,588,762 13.34 8. ITALY 470,648 5,689,120 12.09 9. SPAIN 382,658 4,079,695 10.66 10. AUSTRALIA 338,947 4,098,351 12.09 11. INDIA 334,660 2,059,832 6.15 12. SOUTH KOREA 325,403 2,385,604 7.33 13. NETHERLANDS 276,918 4,376,263 15.80 14. RUSSIA 275,325 1,371,065 4.98

  3. University rankings 3 Nature Publishing Index: 85 Scientist Best Places to Work in Academia: 24 New York Times Employability: 81 Publications In Nature or Science

  4. University-Business cooperation(Netherlands) • Public-Private Partnerships in top-institutes (investigator driven, precompetitive with industry) • Intermediate (industry driven, with investigators) • New: top-sector policy (9 areas, government policy) . Horticulture Agri & Food Water Life sciences & Health Chemistry High tech Energy Logistics Creative industry Head offices

  5. Topsector Life Sciences Healthy Ageing Source: Topsectorplan Life Sciences and Health

  6. University Medical Center 1797 1797

  7. Zernike Science Campus

  8. Relevance to Society Multidisciplinary, University, Industry, Governments & Public Participation 1. Healthy ageing (HANNN) • Biobank & Cohort study Lifelines (165,000 participants) • European Research Institute on the Biology of Ageing ERIBA 2. Energy (Energy Valley) • Energy Academy Europe EAE • Energy Delta Institute EDI • Groningen Centre of Energy Law Energy Academy Europe ENTRANCE: multitesting facility 3. Sustainable Society

  9. www.lifelines.nl Healthy Ageing: LifeLines Relative contributions of genetics and life style to health and disease LifeLines is a prospective cohort study and Biobank that will follow 165,000 participants in a 3-generation design for at least 30 years. The focus is on multifactorial, age-related disorders. Funding: ~120 Million Euro September 2012: 100.000th participant

  10. www.lifelines.nl Healthy Ageing: LifeLines LifeLines cohort dimensions Aselect: 45.000 father Index persons (25-50 years) mother Children: 35.000 child Parents alive: 55.000 child child partner’s father partner Total number of participants: 165.000 partner’s mother Partner: 30.000

  11. European Research Institute on the Biology of Ageing ERIBA Fundamental questions on the biological causes of stem cell ageing

  12. Healthy Ageing Dr. Peter Lansdorp Scientific DirectorTeam Leader: Laboratory of Genetic Instability, Ageing and Cancer ERC advanced grant 2011 European Research Institute on the Biology of Ageing Dr. Ellen Nollen Team Leader: Laboratory of Molecular Neurobiology of Ageing ERC starting grant 2011 Dr. Christian Riedel Team Leader: Laboratory of Molecular Mechanisms in Lifespan Regulation. Dr. Gerald de Haan Scientific Co-DirectorTeam Leader: Laboratory of Ageing Biology and Stem Cells Dr. Victor Guryev Team Leader: Laboratory of Genome Structure and Ageing Dr. Michael Chang Team Leader: Laboratory of Telomeres and Genome Integrity Dr. Floris Foijer Team Leader: Laboratory of Genomic Instability in Development and Disease Dr. Eugene Berezikov Team Leader: Laboratory of Stem Cell Regulation and Mechanisms of Regeneration ERC starting grant 2012 Dr. Liesbeth Veenhoff Team Leader: Laboratory of Cellular Biochemistry: Role of nuclear transport in cellular ageing International team, prestigious European ERC grants

  13. Alliance for Healthy Ageing with Mayo Clinics Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders Darren J. Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K. LeBrasseur, Bennett G. Childs, Bart van de Sluis, James L. Kirkland & Jan M. Van Deursen Nature 479, 232–236 (10 November 2011) Prevents ageing: kyphosis, cataract etc According to Science one of the top 10 scientific discoveries of 2011

  14. Skolkovo TechResearch Investment Strategy Skolkovo Institute of Science and Technology 2012

  15. Skolkovo Tech Strategy – BioMedicine (1) Computational and systems biology – profoundly different approaches to study biological systems, including complex data, in order to support both basic, as well as applied research involving discovery of new drugs and drug targets [high priority] Immunology and infectious disease - in terms of diseases caused by multi-drug resistant bacteria and viral pandemics, the role of microbiome in human health, and organized response to and treatment of disease [high priority, center in negotiation] Gene- and nano-medicine - impacting the understanding of disease, therapeutics and drug delivery [high priority, center in negotiation] Regenerative medicine - stem cell research as well as tissue and organ fabrication [high priority, center in negotiation with ERIBA, University of Groningen]

  16. Hey Charles, Where are you going? To the University of Groningen, always good to get some additional schooling THANK YOU FOR YOUR ATTENTION

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