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Yes n = 94

Enrolled in study n = 165. Excluded n = 29 did not fit criteria for participation (8) withdrew consent (12) steroid withdrawal unsafe (1) LRTI during steroid withdrawal (1) self administered prednisolone during steroid withdrawal (1) unable to produce sputum (6).

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Yes n = 94

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  1. Enrolled in study n = 165 Excluded n = 29 did not fit criteria for participation (8) withdrew consent (12) steroid withdrawal unsafe (1) LRTI during steroid withdrawal (1) self administered prednisolone during steroid withdrawal (1) unable to produce sputum (6) Completed screening for progression to phase 2 n = 136 Objective evidence of airway hyper-responsiveness or bronchodilator response? Excluded n = 48 no objective evidence of airway hyper-responsiveness or bronchodilator response (42) withdrew consent (1) not offered trial of steroid (5) Yes n = 94 Completed trial of steroid n = 88

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