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CAMA-1

A. Supplemental Figure 1. Cyclin E. Actin. B. 10A. 76NF2V. T47D. M4A4. 76N. 76NE7. ZR75-1. MCF-7. HCC38. NM2C5. HCC-1500. MDA-MB-453 (HER2+). Full Length Cyclin E Levels. LMW-E Levels. p=0.003. Cyclin E. Actin. Densitometry Units. HCC-1937. HCC-1954. HCC-1428.

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CAMA-1

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  1. A Supplemental Figure 1 Cyclin E Actin B 10A 76NF2V T47D M4A4 76N 76NE7 ZR75-1 MCF-7 HCC38 NM2C5 HCC-1500 MDA-MB-453 (HER2+) Full Length Cyclin E Levels LMW-E Levels p=0.003 Cyclin E Actin Densitometry Units HCC-1937 HCC-1954 HCC-1428 HCC-1419 (HER2+) DU4475 HCC-1806 UACC-893 (HER2+) AU565 (HER2+) SKBR3 (HER2+) UACC893 (HER2+) BT483 BT549 Cyclin E Immortalized ERα-positive ERα-negative Immortalized ERα-positive ERα-negative Actin Subtype MDA-MB-361 (HER2+) CAMA-1 MDA-MB-415 (Luminal) HCC-1569 (HER2+) BT474 (HER2+) HS578T MDA-MB-231 MDA-MB-468 MDA-MB-436 BT20T MDA-MB-157

  2. Supplemental Table 1

  3. Supplemental Table 2

  4. Supplemental Figure 2 A AhR Actin D 100 250 D 100 250 D 100 250 μM B Control sh-AHR.1 sh-AHR.2 MDA-MB-157 Control shAHR.1 shAHR.2 Normalized Absorbance (590 nM) Log I3C concentration (μM)

  5. Supplemental Figure 3 A B Parental TAM-R Normalized Absorbance (590 nM) Normalized Absorbance (590 nM) Log Tamoxifen concentration (μM) Log I3C concentration (μM)

  6. Supplemental Figure 4 A B p53 MCF-7 T47D p53 Actin ZR75-1 - + - + - + - + I3C (250 μM) MCF-7 Control sh1 sh2 sh3 MDA-MB-436 p53 shRNA MDA-MB-231 MDA-MB-157 PBS DMSO 100 200 300 400 500 I3C (μM) C MCF-7 Control shP53.1 shP53.2 shP53.3 Normalized Absorbance (590 nM) Log I3C concentration (μM)

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