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G  s

C3G. Dbs. Cdc42. Rap-1. MKK4. B-Raf. GPCR. Integrin. GPCR. GPCR. PLC b. Ras. G . bg. bg. G  i/o. Pax. G  q. bg. FAK. Src. Src. Src. G  s. Ca 2+ Store. PI3K. JAK. PKC. MAPKs. STAT3. ERK. p38. ERK. JNK. Cyclin D1. ?.

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G  s

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  1. C3G Dbs Cdc42 Rap-1 MKK4 B-Raf GPCR Integrin GPCR GPCR PLCb Ras G bg bg Gi/o Pax Gq bg FAK Src Src Src Gs Ca2+ Store PI3K JAK PKC MAPKs STAT3 ERK p38 ERK JNK Cyclin D1 ? Transcriptional regulation Transcriptional regulation G1 phase S phase

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