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This comprehensive guide covers early diagnosis, treatment options, survivorship, and support services for breast cancer patients. Learn about risk factors, diagnosis tests, staging, treatment modalities, and the important role of a specialist nurse in the care journey.
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BREAST CANCER Care in Primary Care JOANNE WOODLANDS November 2017
Introduction DIAGNOSIS Role of Breast Cancer Nurse- Local Cancer Care service –referrals and counselling options Breast surgery- post op care Breast cancer treatment :Chemo Radiotherapy Clinical trials/what’s new SURVIVORSHIP /Endocrine therapy Targeted therapy
Early Diagnosis STARTS WITH THE WELL WOMENS CHECK ? Encouraging women to be breast aware and to discuss any changes Encourage Breast Screening – Its free! Management of Breast Symptom- Triple test Patient History Image – MMG USS Breast MRI Biopsy – Core FNAB
Awareness of Risk Factors • The main risk factors • being a woman • getting older • having a strong family history of breast cancer inheriting a faulty gene that increases the risk • Other • Being overweight or obese • Alcohol • Smoking • Personal History of Dense breasts DCIS LCIS • Menstrual History • HRT use
DIAGNOSIS Test Results • Biopsy Pathology result • Type- Invasive or Insitu • Endocrine receptor • Grade • Imaging – size Nodes? • Surgical Histology • Type • Receptors • Oestrogen • Progesterone • Her2 • Grade • Imaging Staging
Genomics • Mammoprint • Oncotype DX
Role of Specialist Breast Cancer Nurse AIMS • Provide Support and Information • Local support services • Encourage high standards of patient care • Optimize Health and wellbeing – Across the various phases • i.e. diagnosis, treatment rehabilitation, advanced cancer care and palliative care.
Nursing Role • Registered Nurse – extra study in Cancer care • Initiate contact as soon as possible after diagnosis or when there is a change in cancer • Referrals from Breast screening and Pre-admission clinics. MDT meetings • Recurrence – Med Oncologist or Rad Onc correspondence. • EBC pathway to exit interview usual end of RT • AdBrCa Pathway - initial then as treatment changes - Advanced Breast Cancer (25 women are presently having Treatment at MNCCI, others will be having endocrine therapy (alone) and managed from private Oncologists rooms Oncologist estimate 30 patients)
Counselling • Advanced Communication skills in BCN Role so able to provide initial counselling and assessment • Management of Anxiety related to Cancer diagnosis • Assessment of other concerns • Safety • Social workers in Cancer care • GP for Mental Health Care Plan and referral to Psychologist • Beyond blue NewAccess (6 sessions) • Mental Health assessment via PMBH emergency.
Other Supports that may Help • Look Good feel Better • Lymphoedema Nurse • ENCORE Exercise program or the Get Healthy NSW health • Dragon Boating • Cancer Council – Telephone support • BCNA • Local Peer support – Group at Library; Pink Girls • Complementary Therapies • Meditation Yoga Psychologist Physiotherapist Exercise Physiologist
Types of Breast Cancer Surgery • The Breast • Breast conserving Surgery • Mastectomy • The Nodes • Sentinel Node • Axillary Sample • Axillary Clearance
Breast Reconstruction • Implant • FLAPs • TRAM / Latissimus dorsi / • DIEP(Deep inferior epigastric artery perforator flap (like the TRAM but uses only Abdo skin and Fat • Other variations
Radiotherapy • IMRT + Boost • Field Whole Breast; Chest Wall Lymph Nodal areas • Hypo fractionation 4 weeks instead of 7weeks • Deep Inspiration Breath Hold (DIBH) • Left side to protect heart • Prone • Protect the Lungs (pendulous Breasts)
Radiotherapy • Skin Care • Eviq • Sorboline • BOZ
Medical Oncology • Chemotherapy • Targeted • Immunotherapy • Endocrine Therapy
Breast cancer treatmentChemotherapy • Triple Negative • Her2 positive • Node positive • High Grade • Neo-adjuvant Vs Adjuvant • Advanced Breast Cancer
Chemotherapy - • Hair loss • Nausea • Hematological- Neutropenic Sepsis • Skin/GIT • Neurological
Breast cancer Treatment Targeted Therapy • Her2 neu receptor positive Breast Cancer • Herceptin (Trastuzumab) • Perjeta (Pertuzumab) with Herceptin • Kadcyla
Clinical trials/what’s new • Keynote - 355 - Study of Pembrolizumab (MK-3475) Plus Chemotherapy vs. Placebo Plus Chemotherapy for Previously Untreated Locally Recurrent Inoperable or Metastatic Triple Negative Breast Cancer (MK-3475-355) • GSK phase 1A Phase I/II Dose Escalation and Expansion Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK525762 in Combination With Fulvestrant in Subjects With ER+ Breast Cancer
Clinical Trials- Radiotherapy • ANZ 1601/BIG 16-02 EXPERT EXamining PErsonalised Radiation Therapy • for low-risk early breast cancer (Risk of Recurrence (ROR) score ≤60 characterised using Prosigna (PAM50) Assay) • A randomised phase III trial of adjuvant radiation therapy versus observation following breast conserving surgery and endocrine therapy in patients with molecularly characterized luminal A early breast cancer • Arm A: RT and endocrine therapy; • Arm B: No RT (endocrine therapy only).
SURVIVORSHIP PLAN– life after Cancer • Surveillance / Fear of Recurrence • Long term side effects • Body image • Hair loss • Scar • Mastectomy • Fatigue • Weight / Exercise • Cardiovascular • Peripheral Neuropathy • Menopause
Breast cancer treatment Endocrine therapy • Oestrogen Receptor and Progestrone Receptor positive • Tamoxifen-Selective estrogen-receptor response modulators (SERMs). • Risk of blood clots, especially in the lungs and legs • Stroke • Cataracts • Endometrialand uterine cancers • Bone loss in premenopausal women • Mood swings, depression, and loss of libido • headaches, nausea, vomiting, skin rash, and decreased sexual interest (impotence in Men)
Breast cancer treatment Endocrine therapy • Aromatase Inhibitors • Risk of heart attack, angina, heart failure, and hypercholesterolemia • Bone loss • Joint pain • Mood swings and depression • Afinitor (Everolimus) an mTOR inhibitoradded to Exemestane • Stomatitis (taste changes) • Pneumonitis • Hyperglycemia • Hyperlipidemia • Nausea
Continue Endocrine Therapy • Estrogen-receptor downregulators (ERDs). Fulvestrant injection IM • Pre-Menopausal - Luteinizing hormone-releasing hormone agents (LHRHs). • E.g. Zoladex or • Oophorectomy
THANK YOU Questions?
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