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Genetic Modifications Beyond Mendelian Ratios

Explore the extensions and variations of Mendelian analysis, including single gene modifications, incomplete dominance, multiple alleles, lethal alleles, and gene pair modifications. Understand complex genetic interactions and expression modifications.

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Genetic Modifications Beyond Mendelian Ratios

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  1. Extensions of Mendelian Analysis • Modifications of Mendelian Ratios • Single Gene modifications • Two gene pair modifications: modified 9:3:3:1 ratios • Modification of Expression

  2. Single Gene modifications • Incomplete dominance (partial dominance) • Multiple alleles • Lethal alleles

  3. Incomplete dominance (partial dominance) • Expression of a heterozygous phenotype that is distinct from and usually intermediate to either homozygous phenotype

  4. Incomplete dominance (partial dominance) Tay Sachs and Sickle Cell Anemia Heterozygous are intermediate at the biochemical level.

  5. Multiple Alleles &Co-Dominance

  6. Bombay phenotype • H allele affected • Recessive epistasis • Show O phenotype • Genotype variable

  7. Lethal alleles • Yellow dominant to Agouti coat color • No purebred yellow • Deletion mutation • Recessive for lethality

  8. Two gene pair modifications: modified 9:3:3:1 ratios • Epistasis • Suppression • Complementary gene action

  9. Recessive Epistasis

  10. Dominant Epistasis

  11. Suppression

  12. Complementary gene action

  13. Complementary gene action

  14. Modification of Expression • Pleiotropic effects • Penetrance and Expressivity

  15. Pleiotropic effects

  16. Penetrance No expression

  17. Expressivity

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